G protein-activated inward rectifier potassium channel 3 (GIRK-3) (Inward rectifier K(+) channel Kir3.3) (Potassium channel, inwardly rectifying subfamily J member 9)
1_MAQEN 6_ AAFSP 11_ GQEEP 16_ PRRRG 21_ RQRYV 26_ EKDGR 31_ CNVQQ 36_ GNVRE 41_ TYRYL 46_ TDLFT 51_ TLVDL 56_ QWRLS 61_ LLFFV 66_ LAYAL 71_ TWLFF 76_ GAIWW 81_ LIAYG 86_ RGDLE 91_ HLEDT 96_ AWTPC 101_ VNNLN 106_ GFVAA 111_ FLFSI 116_ ETETT 121_ IGYGH 126_ RVITD 131_ QCPEG 136_ IVLLL 141_ LQAIL 146_ GSMVN 151_ AFMVG 156_ CMFVK 161_ ISQPN 166_ KRAAT 171_ LVFSS 176_ HAVVS 181_ LRDGR 186_ LCLMF 191_ RVGDL 196_ RSSHI 201_ VEASI 206_ RAKLI 211_ RSRQT 216_ LEGEF 221_ IPLHQ 226_ TDLSV 231_ GFDTG 236_ DDRLF 241_ LVSPL 246_ VISHE 251_ IDAAS 256_ PFWEA 261_ SRRAL 266_ ERDDF 271_ EIVVI 276_ LEGMV 281_ EATGM 286_ TCQAR 291_ SSYLV 296_ DEVLW 301_ GHRFT 306_ SVLTL 311_ EDGFY 316_ EVDYA 321_ SFHET 326_ FEVPT 331_ PSCSA 336_ RELAE 341_ AAARL 346_ DAHLY 351_ WSIPS 356_ RLDEK 361_ VEEEG 366_ AGEGA 371_ GGEAG 376_ ADKEQ 381_ NGCLP 386_PPESE
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium, This receptor is controlled by G proteins. Unable to produce channel activity when expressed alone (PubMed:10659995). Forms a functional channel in association with KCNJ3/GIRK1 (By similarity)