Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase)
1_MGILS 6_ VDLLI 11_ TLQIL 16_ PVFFS 21_ NCLFL 26_ ALYDS 31_ VILLK 36_ HVVLL 41_ LSRSK 46_ STRGE 51_ WRRML 56_ TSEGL 61_ RCVWK 66_ SFLLD 71_ AYKQV 76_ KLGED 81_ APNSS 86_ VVHVS 91_ STEGG 96_ DNSGN 101_ GTQEK 106_ IAEGA 111_ TCHLL 116_ DFASP 121_ ERPLV 126_ VNFGS 131_ ATUPP 136_ FTSQL 141_ PAFRK 146_ LVEEF 151_ SSVAD 156_ FLLVY 161_ IDEAH 166_ PSDGW 171_ AIPGD 176_ SSLSF 181_ EVKKH 186_ QNQED 191_ RCAAA 196_ QQLLE 201_ RFSLP 206_ PQCRV 211_ VADRM 216_ DNNAN 221_ IAYGV 226_ AFERV 231_ CIVQR 236_ QKIAY 241_ LGGKG 246_ PFSYN 251_ LQEVR 256_ HWLEK 261_ NFSKR 266_UKKTR
1: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722, PubMed:18339710). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (PubMed:18339710)