Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)
1_MHCER 6_ FLCIL 11_ RIIGT 16_ TLFGV 21_ SLLLG 26_ ITAAY 31_ IVGYQ 36_ FIQTD 41_ NYYFS 46_ FGLYG 51_ AFLAS 56_ HLIIQ 61_ SLFAF 66_ LEHRK 71_ MKKSL 76_ ETPIK 81_ LNKTV 86_ ALCIA 91_ AYQED 96_ PDYLR 101_ KCLQS 106_ VKRLT 111_ YPGIK 116_ VVMVI 121_ DGNSE 126_ DDLYM 131_ MDIFS 136_ EVMGR 141_ DKSAT 146_ YIWKN 151_ NFHEK 156_ GPGET 161_ DESHK 166_ ESSQH 171_ VTQLV 176_ LSNKS 181_ ICIMQ 186_ KWGGK 191_ REVMY 196_ TAFRA 201_ LGRSV 206_ DYVQV 211_ CDSDT 216_ MLDPA 221_ SSVEM 226_ VKVLE 231_ EDPMV 236_ GGVGG 241_ DVQIL 246_ NKYDS 251_ WISFL 256_ SSVRY 261_ WMAFN 266_ IERAC 271_ QSYFG 276_ CVQCI 281_ SGPLG 286_ MYRNS 291_ LLHEF 296_ VEDWY 301_ NQEFM 306_ GNQCS 311_ FGDDR 316_ HLTNR 321_ VLSLG 326_ YATKY 331_ TARSK 336_ CLTET 341_ PIEYL 346_ RWLNQ 351_ QTRWS 356_ KSYFR 361_ EWLYN 366_ AMWFH 371_ KHHLW 376_ MTYEA 381_ IITGF 386_ FPFFL 391_ IATVI 396_ QLFYR 401_ GKIWN 406_ ILLFL 411_ LTVQL 416_ VGLIK 421_ SSFAS 426_ CLRGN 431_ IVMVF 436_ MSLYS 441_ VLYMS 446_ SLLPA 451_ KMFAI 456_ ATINK 461_ AGWGT 466_ SGRKT 471_ IVVNF 476_ IGLIP 481_ VSVWF 486_ TILLG 491_ GVIFT 496_ IYKES 501_ KRPFS 506_ ESKQT 511_ VLIVG 516_ TLLYA 521_ CYWVM 526_ LLTLY 531_ VVLIN 536_ KCGRR 541_ KKGQQ 546_YDMVL
1: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable) (PubMed:20507985, PubMed:21228273, PubMed:23303191, PubMed:32993960). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:20507985, PubMed:21228273, PubMed:8798477). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)