Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)
1_MASPG 6_ CLLCV 11_ LGLLL 16_ CGAAS 21_ LELSR 26_ PHGDT 31_ AKKPI 36_ IGILM 41_ QKCRN 46_ KVMKN 51_ YGRYY 56_ IAASY 61_ VKYLE 66_ SAGAR 71_ VVPVR 76_ LDLTE 81_ KDYEI 86_ LFKSI 91_ NGILF 96_ PGGSV 101_ DLRRS 106_ DYAKV 111_ AKIFY 116_ NLSIQ 121_ SFDDG 126_ DYFPV 131_ WGTCL 136_ GFEEL 141_ SLLIS 146_ GECLL 151_ TATDT 156_ VDVAM 161_ PLNFT 166_ GGQLH 171_ SRMFQ 176_ NFPTE 181_ LLLSL 186_ AVEPL 191_ TANFH 196_ KWSLS 201_ VKNFT 206_ MNEKL 211_ KKFFN 216_ VLTTN 221_ TDGKI 226_ EFIST 231_ MEGYK 236_ YPVYG 241_ VQWHP 246_ EKAPY 251_ EWKNL 256_ DGISH 261_ APNAV 266_ KTAFY 271_ LAEFF 276_ VNEAR 281_ KNNHH 286_ FKSES 291_ EEEKA 296_ LIYQF 301_ SPIYT 306_ GNISS 311_FQQCY
1: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates