Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)
1_MGWGS 6_ RCCCP 11_ GRLDL 16_ LCVLA 21_ LLGGC 26_ LLPVC 31_ RTRVY 36_ TNHWA 41_ VKIAG 46_ GFPEA 51_ NRIAS 56_ KYGFI 61_ NIGQI 66_ GALKD 71_ YYHFY 76_ HSRTI 81_ KRSVI 86_ SSRGT 91_ HSFIS 96_ MEPKV 101_ EWIQQ 106_ QVVKK 111_ RTKRD 116_ YDFSR 121_ AQSTY 126_ FNDPK 131_ WPSMW 136_ YMHCS 141_ DNTHP 146_ CQSDM 151_ NIEGA 156_ WKRGY 161_ TGKNI 166_ VVTIL 171_ DDGIE 176_ RTHPD 181_ LMQNY 186_ DALAS 191_ CDVNG 196_ NDLDP 201_ MPRYD 206_ ASNEN 211_ KHGTR 216_ CAGEV 221_ AAAAN 226_ NSHCT 231_ VGIAF 236_ NAKIG 241_ GVRML 246_ DGDVT 251_ DMVEA 256_ KSVSF 261_ NPQHV 266_ HIYSA 271_ SWGPD 276_ DDGKT 281_ VDGPA 286_ PLTRQ 291_ AFENG 296_ VRMGR 301_ RGLGS 306_ VFVWA 311_ SGNGG 316_ RSKDH 321_ CSCDG 326_ YTNSI 331_ YTISI 336_ SSTAE 341_ SGKKP 346_ WYLEE 351_ CSSTL 356_ ATTYS 361_ SGESY 366_ DKKII 371_ TTDLR 376_ QRCTD 381_ NHTGT 386_ SASAP 391_ MAAGI 396_ IALAL 401_ EANPF 406_ LTWRD 411_ VQHVI 416_ VRTSR 421_ AGHLN 426_ ANDWK 431_ TNAAG 436_ FKVSH 441_ LYGFG 446_ LMDAE 451_ AMVME 456_ AEKWT 461_ TVPRQ 466_ HVCVE 471_ STDRQ 476_ IKTIR 481_ PNSAV 486_ RSIYK 491_ ASGCS 496_ DNPNR 501_ HVNYL 506_ EHVVV 511_ RITIT 516_ HPRRG 521_ DLAIY 526_ LTSPS 531_ GTRSQ 536_ LLANR 541_ LFDHS 546_ MEGFK 551_ NWEFM 556_ TIHCW 561_ GERAA 566_ GDWVL 571_ EVYDT 576_ PSQLR 581_ NFKTP 586_ GKLKE 591_ WSLVL 596_ YGTSV 601_ QPYSP 606_ TNEFP 611_ KVERF 616_ RYSRV 621_ EDPTD 626_ DYGTE 631_ DYAGP 636_ CDPEC 641_ SEVGC 646_ DGPGP 651_ DHCND 656_ CLHYY 661_ YKLKN 666_ NTRIC 671_ VSSCP 676_ PGHYH 681_ ADKKR 686_ CRKCA 691_ PNCES 696_ CFGSH 701_ GDQCM 706_ SCKYG 711_ YFLNE 716_ ETNSC 721_ VTHCP 726_ DGSYQ 731_ DTKKN 736_ LCRKC 741_ SENCK 746_ TCTEF 751_ HNCTE 756_ CRDGL 761_ SLQGS 766_ RCSVS 771_ CEDGR 776_ YFNGQ 781_ DCQPC 786_ HRFCA 791_ TCAGA 796_ GADGC 801_ INCTE 806_ GYFME 811_ DGRCV 816_ QSCSI 821_ SYYFD 826_ HSSEN 831_ GYKSC 836_ KKCDI 841_ SCLTC 846_ NGPGF 851_ KNCTS 856_ CPSGY 861_ LLDLG 866_ MCQMG 871_ AICKD 876_ GEYVD 881_ EHGHC 886_ QTCEA 891_ SCAKC 896_ QGPTQ 901_ EDCTT 906_ CPMTR 911_ IFDDG 916_ RCVSN 921_ CPSWK 926_ FEFEN 931_ QCHPC 936_ HHTCQ 941_ RCQGS 946_ GPTHC 951_ TSCGA 956_ DNYGR 961_ EHFLY 966_ QGECG 971_ DSCPE 976_ GHYAT 981_ EGNTC 986_ LPCPD 991_ NCELC 996_ HSVHV 1001_ CTRCM 1006_ KGYFI 1011_ APTNH 1016_ TCQKL 1021_ ECGQG 1026_ EVQDP 1031_ DYEEC 1036_ VPCEE 1041_ GCLGC 1046_ SLDDP 1051_ GTCTS 1056_ CAMGY 1061_ YRFDH 1066_ HCYKT 1071_ CPEKT 1076_ YSEEV 1081_ ECKAC 1086_ DSNCG 1091_ SCDQN 1096_ GCYWC 1101_ EEGFF 1106_ LLGGS 1111_ CVRKC 1116_ GPGFY 1121_ GDQEM 1126_ GECES 1131_ CHRAC 1136_ ETCTG 1141_ PGHDE 1146_ CSSCQ 1151_ EGLQL 1156_ LRGMC 1161_ VHATK 1166_ TQEEG 1171_ KFWND 1176_ ILRKL 1181_ QPCHS 1186_ SCKTC 1191_ NGSAT 1196_ LCTSC 1201_ PKGAY 1206_ LLAQA 1211_ CVSSC 1216_ PQGTW 1221_ PSVRS 1226_ GSCEN 1231_ CTEAC 1236_ AICSG 1241_ ADLCK 1246_ KCQMQ 1251_ PGHPL 1256_ FLHEG 1261_ RCYSK 1266_ CPEGS 1271_ YAEDG 1276_ ICERC 1281_ SSPCR 1286_ TCEGN 1291_ ATNCH 1296_ SCEGG 1301_ HVLHH 1306_ GVCQE 1311_ NCPER 1316_ HVAVK 1321_ GVCKH 1326_ CPEMC 1331_ QDCIH 1336_ EKTCK 1341_ ECTPE 1346_ FFLHD 1351_ DMCHQ 1356_ SCPRG 1361_ FYADS 1366_ RHCVP 1371_ CHKDC 1376_ LECSG 1381_ PKADD 1386_ CELCL 1391_ ESSWV 1396_ LYDGL 1401_ CLEEC 1406_ PAGTY 1411_ YEKET 1416_ KECRD 1421_ CHKSC 1426_ LTCSS 1431_ SGTCT 1436_ TCQKG 1441_ LIMNP 1446_ RGSCM 1451_ ANEKC 1456_ SPSEY 1461_ WDEDA 1466_ PGCKP 1471_ CHVKC 1476_ FHCMG 1481_ PAEDQ 1486_ CQTCP 1491_ MNSLL 1496_ LNTTC 1501_ VKDCP 1506_ EGYYA 1511_ DEDSN 1516_ RCAHC 1521_ HSSCR 1526_ TCEGR 1531_ HSRQC 1536_ HSCRP 1541_ GWFQL 1546_ GKECL 1551_ LQCRE 1556_ GYYAD 1561_ NSTGR 1566_ CERCN 1571_ RSCKG 1576_ CQGPR 1581_ PTDCL 1586_ SCDRF 1591_ FFLLR 1596_ SKGEC 1601_ HRSCP 1606_ DHYYV 1611_ EQSTQ 1616_ TCERC 1621_ HPTCD 1626_ QCKGK 1631_ GALNC 1636_ LSCVW 1641_ SYHLM 1646_ GGICT 1651_ SDCLV 1656_ GEYRV 1661_ GEGEK 1666_ FNCEK 1671_ CHESC 1676_ MECKG 1681_ PGAKN 1686_ CTLCP 1691_ ANLVL 1696_ HMDDS 1701_ HCLHC 1706_ CNTSD 1711_ PPSAQ 1716_ ECCDC 1721_ QDTTD 1726_ ECILR 1731_ TSKVR 1736_ PATEH 1741_ FKTAL 1746_ FITSS 1751_ MMLVL 1756_ LLGAA 1761_ VVVWK 1766_ KSRGR 1771_ VQPAA 1776_ KAGYE 1781_ KLADP 1786_ NKSYS 1791_ SYKSS 1796_ YREST 1801_ SFEED 1806_ QVIEY 1811_ RDRDY 1816_ DEDDD 1821_ DDIVY 1826_ MGQDG 1831_ TVYRK 1836_ FKYGL 1841_ LDDDD 1846_ IDELE 1851_YDDES
1: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins