Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)
1_MAEPS 6_ QAPTP 11_ APAAQ 16_ PRPLQ 21_ SPAPA 26_ PTPTP 31_ APSPA 36_ SAPIP 41_ TPTPA 46_ PAPAP 51_ AAAPA 56_ GSTGT 61_ GGPGV 66_ GSGGA 71_ GSGGD 76_ PARPG 81_ LSQQQ 86_ RASQR 91_ KAQVR 96_ GLPRA 101_ KKLEK 106_ LGVFS 111_ ACKAN 116_ ETCKC 121_ NGWKN 126_ PKPPT 131_ APRMD 136_ LQQPA 141_ ANLSE 146_ LCRSC 151_ EHPLA 156_ DHVSH 161_ LENVS 166_ EDEIN 171_ RLLGM 176_ VVDVE 181_ NLFMS 186_ VHKEE 191_ DTDTK 196_ QVYFY 201_ LFKLL 206_ RKCIL 211_ QMTRP 216_ VVEGS 221_ LGSPP 226_ FEKPN 231_ IEQGV 236_ LNFVQ 241_ YKFSH 246_ LAPRE 251_ RQTMF 256_ ELSKM 261_ FLLCL 266_ NYWKL 271_ ETPAQ 276_ FRQRS 281_ QAEDV 286_ ATYKV 291_ NYTRW 296_ LCYCH 301_ VPQSC 306_ DSLPR 311_ YETTH 316_ VFGRS 321_ LLRSI 326_ FTVTR 331_ RQLLE 336_ KFRVE 341_ KDKLV 346_ PEKRT 351_ LILTH 356_ FPKFL 361_ SMLEE 366_ EIYGA 371_ NSPIW 376_ ESGFT 381_ MPPSE 386_ GTQLV 391_ PRPAS 396_ VSAAV 401_ VPSTP 406_ IFSPS 411_ MGGGS 416_ NSSLS 421_ LDSAG 426_ AEPMP 431_ GEKRT 436_ LPENL 441_ TLEDA 446_ KRLRV 451_ MGDIP 456_ MELVN 461_ EVMLT 466_ ITDPA 471_ AMLGP 476_ ETSLL 481_ SANAA 486_ RDETA 491_ RLEER 496_ RGIIE 501_ FHVIG 506_ NSLTP 511_ KANRR 516_ VLLWL 521_ VGLQN 526_ VFSHQ 531_ LPRMP 536_ KEYIA 541_ RLVFD 546_ PKHKT 551_ LALIK 556_ DGRVI 561_ GGICF 566_ RMFPT 571_ QGFTE 576_ IVFCA 581_ VTSNE 586_ QVKGY 591_ GTHLM 596_ NHLKE 601_ YHIKH 606_ NILYF 611_ LTYAD 616_ EYAIG 621_ YFKKQ 626_ GFSKD 631_ IKVPK 636_ SRYLG 641_ YIKDY 646_ EGATL 651_ MECEL 656_ NPRIP 661_ YTELS 666_ HIIKK 671_ QKEII 676_ KKLIE 681_ RKQAQ 686_ IRKVY 691_ PGLSC 696_ FKEGV 701_ RQIPV 706_ ESVPG 711_ IRETG 716_ WKPLG 721_ KEKGK 726_ ELKDP 731_ DQLYT 736_ TLKNL 741_ LAQIK 746_ SHPSA 751_ WPFME 756_ PVKKS 761_ EAPDY 766_ YEVIR 771_ FPIDL 776_ KTMTE 781_ RLRSR 786_ YYVTR 791_ KLFVA 796_ DLQRV 801_ IANCR 806_ EYNPP 811_ DSEYC 816_ RCASA 821_ LEKFF 826_ YFKLK 831_EGGLI
1: Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context (PubMed:29211711, PubMed:35995428). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755, PubMed:21131905). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (PubMed:21131905). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, MRE11, PPARGC1A, PLK4 and TBX5 (PubMed:16753578, PubMed:17301242, PubMed:27796307, PubMed:29174768, PubMed:38128537). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (PubMed:16753578, PubMed:23142079). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297)
2: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes