Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
1_MSEAG 6_ GAGPG 11_ GCGAG 16_ AGAGA 21_ GPGAL 26_ PPQPA 31_ ALPPA 36_ PPQGS 41_ PCAAA 46_ AGGSG 51_ ACGPA 56_ TAVAA 61_ AGTAE 66_ GPGGG 71_ GSARI 76_ AVKKA 81_ QLRSA 86_ PRAKK 91_ LEKLG 96_ VYSAC 101_ KAEES 106_ CKCNG 111_ WKNPN 116_ PSPTP 121_ PRADL 126_ QQIIV 131_ SLTES 136_ CRSCS 141_ HALAA 146_ HVSHL 151_ ENVSE 156_ EEMNR 161_ LLGIV 166_ LDVEY 171_ LFTCV 176_ HKEED 181_ ADTKQ 186_ VYFYL 191_ FKLLR 196_ KSILQ 201_ RGKPV 206_ VEGSL 211_ EKKPP 216_ FEKPS 221_ IEQGV 226_ NNFVQ 231_ YKFSH 236_ LPAKE 241_ RQTIV 246_ ELAKM 251_ FLNRI 256_ NYWHL 261_ EAPSQ 266_ RRLRS 271_ PNDDI 276_ SGYKE 281_ NYTRW 286_ LCYCN 291_ VPQFC 296_ DSLPR 301_ YETTQ 306_ VFGRT 311_ LLRSV 316_ FTVMR 321_ RQLLE 326_ QARQE 331_ KDKLP 336_ LEKRT 341_ LILTH 346_ FPKFL 351_ SMLEE 356_ EVYSQ 361_ NSPIW 366_ DQDFL 371_ SASSR 376_ TSQLG 381_ IQTVI 386_ NPPPV 391_ AGTIS 396_ YNSTS 401_ SSLEQ 406_ PNAGS 411_ SSPAC 416_ KASSG 421_ LEANP 426_ GEKRK 431_ MTDSH 436_ VLEEA 441_ KKPRV 446_ MGDIP 451_ MELIN 456_ EVMST 461_ ITDPA 466_ AMLGP 471_ ETNFL 476_ SAHSA 481_ RDEAA 486_ RLEER 491_ RGVIE 496_ FHVVG 501_ NSLNQ 506_ KPNKK 511_ ILMWL 516_ VGLQN 521_ VFSHQ 526_ LPRMP 531_ KEYIT 536_ RLVFD 541_ PKHKT 546_ LALIK 551_ DGRVI 556_ GGICF 561_ RMFPS 566_ QGFTE 571_ IVFCA 576_ VTSNE 581_ QVKGY 586_ GTHLM 591_ NHLKE 596_ YHIKH 601_ DILNF 606_ LTYAD 611_ EYAIG 616_ YFKKQ 621_ GFSKE 626_ IKIPK 631_ TKYVG 636_ YIKDY 641_ EGATL 646_ MGCEL 651_ NPRIP 656_ YTEFS 661_ VIIKK 666_ QKEII 671_ KKLIE 676_ RKQAQ 681_ IRKVY 686_ PGLSC 691_ FKDGV 696_ RQIPI 701_ ESIPG 706_ IRETG 711_ WKPSG 716_ KEKSK 721_ EPRDP 726_ DQLYS 731_ TLKSI 736_ LQQVK 741_ SHQSA 746_ WPFME 751_ PVKRT 756_ EAPGY 761_ YEVIR 766_ FPMDL 771_ KTMSE 776_ RLKNR 781_ YYVSK 786_ KLFMA 791_ DLQRV 796_ FTNCK 801_ EYNPP 806_ ESEYY 811_ KCANI 816_ LEKFF 821_ FSKIK 826_EAGLI
1: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (PubMed:21131905). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5 (PubMed:10675335, PubMed:23001180, PubMed:23932781, PubMed:26867678, PubMed:27796307, PubMed:29174768, PubMed:9707565). Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678). Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis (PubMed:23001180). Also acetylates spermidine (PubMed:27389534)
2: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes