Protein Jumonji (Jumonji/ARID domain-containing protein 2)
1_MSKER 6_ PKRNI 11_ IQKKY 16_ DDSDG 21_ IPWSE 26_ ERVVR 31_ KVLYL 36_ SLKEF 41_ KNSQK 46_ RQHAE 51_ GIAGS 56_ LKTVN 61_ GLLGN 66_ DQSKG 71_ LGPAS 76_ EQSEN 81_ EKDDA 86_ SQVSS 91_ TSNDV 96_ SSSDF 101_ EEGPS 106_ RKRPR 111_ LQAQR 116_ KFAQS 121_ QPNSP 126_ STTPV 131_ KIVEP 136_ LLPPP 141_ ATQIS 146_ DLSKR 151_ KPKTE 156_ DFLTF 161_ LCLRG 166_ SPALP 171_ NSMVY 176_ FGSSQ 181_ DEEEV 186_ EEEDD 191_ ETEDV 196_ KTATN 201_ NASSS 206_ CQSTP 211_ RKGKT 216_ HKHVH 221_ NGHVF 226_ NGSSR 231_ STREK 236_ EPVQK 241_ HKSKE 246_ ATPAK 251_ EKHSD 256_ HRADS 261_ RREQA 266_ SANHP 271_ AAAPS 276_ TGSSA 281_ KGLAA 286_ THHHP 291_ PLHRS 296_ AQDLR 301_ KQVSK 306_ VNGVT 311_ RMSSL 316_ GAGVT 321_ SAKKM 326_ REVRP 331_ SPSKT 336_ VKYTA 341_ TVTKG 346_ AVTYT 351_ KAKRE 356_ LVKDT 361_ KPNHH 366_ KPSSA 371_ VNHTI 376_ SGKTE 381_ SSNAK 386_ TRKQV 391_ LSLGG 396_ ASKST 401_ GPAVN 406_ GLKVS 411_ GRLNP 416_ KSCTK 421_ EVGGR 426_ QLREG 431_ LQLRE 436_ GLRNS 441_ KRRLE 446_ EAHQA 451_ EKPQS 456_ PPKKM 461_ KGAAG 466_ PAEGP 471_ GKKAP 476_ AERGL 481_ LNGHV 486_ KKEVP 491_ ERSLE 496_ RNRPK 501_ RATAG 506_ KSTPG 511_ RQAHG 516_ KADSA 521_ SCENR 526_ STSQP 531_ ESVHK 536_ PQDSG 541_ KAEKG 546_ GGKAG 551_ WAAMD 556_ EIPVL 561_ RPSAK 566_ EFHDP 571_ LIYIE 576_ SVRAQ 581_ VEKFG 586_ MCRVI 591_ PPPDW 596_ RPECK 601_ LNDEM 606_ RFVTQ 611_ IQHIH 616_ KLGRR 621_ WGPNV 626_ QRLAC 631_ IKKHL 636_ KSQGI 641_ TMDEL 646_ PLIGG 651_ CELDL 656_ ACFFR 661_ LINEM 666_ GGMQQ 671_ VTDLK 676_ KWNKL 681_ ADMLR 686_ IPRTA 691_ QDRLA 696_ KLQEA 701_ YCQYL 706_ LSYDS 711_ LSPEE 716_ HRRLE 721_ KEVLM 726_ EKEIL 731_ EKRKG 736_ PLEGH 741_ TENDH 746_ HKFHP 751_ LPRFE 756_ PKNGL 761_ IHGVA 766_ PRNGF 771_ RSKLK 776_ EVGQA 781_ QLKTG 786_ RRRLF 791_ AQEKE 796_ VVKEE 801_ EEDKG 806_ VLNDF 811_ HKCIY 816_ KGRSV 821_ SLTTF 826_ YRTAR 831_ NIMSM 836_ CFSKE 841_ PAPAE 846_ IEQEY 851_ WRLVE 856_ EKDCH 861_ VAVHC 866_ GKVDT 871_ NTHGS 876_ GFPVG 881_ KSEPF 886_ SRHGW 891_ NLTVL 896_ PNNTG 901_ SILRH 906_ LGAVP 911_ GVTIP 916_ WLNIG 921_ MVFST 926_ SCWSR 931_ DQNHL 936_ PYIDY 941_ LHTGA 946_ DCIWY 951_ CIPAE 956_ EENKL 961_ EDVVH 966_ TLLQA 971_ NGTPG 976_ LQMLE 981_ SNVMI 986_ SPEVL 991_ CKEGI 996_ KVHRT 1001_ VQQSG 1006_ QFVVC 1011_ FPGSF 1016_ VSKVC 1021_ CGYSV 1026_ SETVH 1031_ FATTQ 1036_ WTSMG 1041_ FETAK 1046_ EMKRR 1051_ HIAKP 1056_ FSMEK 1061_ LLYQI 1066_ AQAEA 1071_ KKENG 1076_ PTLST 1081_ ISALL 1086_ DELRD 1091_ TELRQ 1096_ RRQLF 1101_ EAGLH 1106_ SSARY 1111_ GSHDG 1116_ SSTVA 1121_ DGKKK 1126_ PRKWL 1131_ QLETS 1136_ ERRCQ 1141_ ICQHL 1146_ CYLSM 1151_ VVQEN 1156_ ENVVF 1161_ CLECA 1166_ LRHVE 1171_ KQKSC 1176_ RGLKL 1181_ MYRYD 1186_ EEQII 1191_ SLVNQ 1196_ ICGKV 1201_ SGKNG 1206_ SIENC 1211_ LSKPT 1216_ PKRGP 1221_ RKRAT 1226_ VDVPP 1231_ SRLSA 1236_ SSSSK 1241_SASSS
1: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity)