X-linked retinitis pigmentosa GTPase regulator
1_MREPE 6_ ELMPD 11_ SGAVF 16_ TFGKS 21_ KFAEN 26_ NPGKF 31_ WFKND 36_ VPVHL 41_ SCGDE 46_ HSAVV 51_ TGNNK 56_ LYMFG 61_ SNNWG 66_ QLGLG 71_ SKSAI 76_ SKPTC 81_ VKALK 86_ PEKVK 91_ LAACG 96_ RNHTL 101_ VSTEG 106_ GNVYA 111_ TGGNN 116_ EGQLG 121_ LGDTE 126_ ERNTF 131_ HVISF 136_ FTSEH 141_ KIKQL 146_ SAGSN 151_ TSAAL 156_ TEDGR 161_ LFMWG 166_ DNSEG 171_ QIGLK 176_ NVSNV 181_ CVPQQ 186_ VTIGK 191_ PVSWI 196_ SCGYY 201_ HSAFV 206_ TTDGE 211_ LYVFG 216_ EPENG 221_ KLGLP 226_ NQLLG 231_ NHRTP 236_ QLVSE 241_ IPEKV 246_ IQVAC 251_ GGEHT 256_ VVLTE 261_ NAVYT 266_ FGLGQ 271_ FGQLG 276_ LGTFL 281_ FETSE 286_ PKVIE 291_ NIRDQ 296_ TISYI 301_ SCGEN 306_ HTALI 311_ TDIGL 316_ MYTFG 321_ DGRHG 326_ KLGLG 331_ LENFT 336_ NHFIP 341_ TLCSN 346_ FLRFI 351_ VKLVA 356_ CGGCH 361_ MVVFA 366_ APHRG 371_ VAKEI 376_ EFDEI 381_ NDTCL 386_ SVATF 391_ LPYSS 396_ LTSGN 401_ VLQRT 406_ LSARM 411_ RRRER 416_ ERSPD 421_ SFSMR 426_ RTLPP 431_ IEGTL 436_ GLSAC 441_ FLPNS 446_ VFPRC 451_ SERNL 456_ QESVL 461_ SEQDL 466_ MQPEE 471_ PDYLL 476_ DEMTK 481_ EAEID 486_ NSSTV 491_ ESLGE 496_ TTDIL 501_ NMTHI 506_ MSLNS 511_ NEKSL 516_ KLSPV 521_ QKQKK 526_ QQTIG 531_ ELTQD 536_ TALTE 541_ NDDSD 546_ EYEEM 551_ SEMKE 556_ GKACK 561_ QHVSQ 566_ GIFMT 571_ QPATT 576_ IEAFS 581_ DEEVG 586_ NDTGQ 591_ VGPQA 596_ DTDGE 601_ GLQKE 606_ VYRHE 611_ NNNGV 616_ DQLDA 621_ KEIEK 626_ ESDGG 631_ HSQKE 636_ SEAEE 641_ IDSEK 646_ ETKLA 651_ EIAGM 656_ KDLRE 661_ REKST 666_ KKMSP 671_ FFGNL 676_ PDRGM 681_ NTESE 686_ ENKDF 691_ VKKRE 696_ SCKQD 701_ VIFDS 706_ ERESV 711_ EKPDS 716_ YMEGA 721_ SESQQ 726_ GIADG 731_ FQQPE 736_ AIEFS 741_ SGEKE 746_ DDEVE 751_ TDQNI 756_ RYGRK 761_ LIEQG 766_ NEKET 771_ KPIIS 776_ KSMAK 781_ YDFKC 786_ DRLSE 791_ IPEEK 796_ EGAED 801_ SKGNG 806_ IEEQE 811_ VEANE 816_ ENVKV 821_ HGGRK 826_ EKTEI 831_ LSDDL 836_ TDKAE 841_ DHEFS 846_ KTEEL 851_ KLEDV 856_ DEEIN 861_ AENVE 866_ SKKKT 871_ VGDDE 876_ SVPTG 881_ YHSKT 886_ EGAER 891_ TNDDS 896_ SAETI 901_ EKKEK 906_ ANLEE 911_ RAICE 916_ YNENP 921_ KGYML 926_ DDADS 931_ SSLEI 936_ LENSE 941_ TTPSK 946_ DMKKT 951_ KKIFL 956_ FKRVP 961_ SINQK 966_ IVKNN 971_ NEPLP 976_ EIKSI 981_ GDQII 986_ LKSDN 991_ KDADQ 996_ NHMSQ 1001_ NHQNI 1006_ PPTNT 1011_ERRSK
1: Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:20631154). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (PubMed:20631154). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (By similarity). Involved in photoreceptor integrity (By similarity). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (PubMed:21933838). May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity)