Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
1_MVPCW 6_ NHGNI 11_ TRSKA 16_ EELLS 21_ RTGKD 26_ GSFLV 31_ RASES 36_ ISRAY 41_ ALCVL 46_ YRNCV 51_ YTYRI 56_ LPNED 61_ DKFTV 66_ QASEG 71_ VSMRF 76_ FTKLD 81_ QLIEF 86_ YKKEN 91_ MGLVT 96_ HLQYP 101_ VPLEE 106_ EDTGD 111_ DPEED 116_ TVESV 121_ VSPPE 126_ LPPRN 131_ IPLTA 136_ SSCEA 141_ KEVPF 146_ SNENP 151_ RATET 156_ SRPSL 161_ SETLF 166_ QRLQS 171_ MDTSG 176_ LPEEH 181_ LKAIQ 186_ DYLST 191_ QLAQD 196_ SEFVK 201_ TGSSS 206_ LPHLK 211_ KLTTL 216_ LCKEL 221_ YGEVI 226_ RTLPS 231_ LESLQ 236_ RLFDQ 241_ QLSPG 246_ LRPRP 251_ QVPGE 256_ ANPIN 261_ MVSKL 266_ SQLTS 271_ LLSSI 276_ EDKVK 281_ ALLHE 286_ GPESP 291_ HRPSL 296_ IPPVT 301_ FEVKA 306_ ESLGI 311_ PQKMQ 316_ LKVDV 321_ ESGKL 326_ IIKKS 331_ KDGSE 336_ DKFYS 341_ HKKIL 346_ QLIKS 351_ QKFLN 356_ KLVIL 361_ VETEK 366_ EKILR 371_ KEYVF 376_ ADSKK 381_ REGFC 386_ QLLQQ 391_ MKNKH 396_ SEQPE 401_ PDMIT 406_ IFIGT 411_ WNMGN 416_ APPPK 421_ KITSW 426_ FLSKG 431_ QGKTR 436_ DDSAD 441_ YIPHD 446_ IYVIG 451_ TQEDP 456_ LSEKE 461_ WLEIL 466_ KHSLQ 471_ EITSV 476_ TFKTV 481_ AIHTL 486_ WNIRI 491_ VVLAK 496_ PEHEN 501_ RISHI 506_ CTDNV 511_ KTGIA 516_ NTLGN 521_ KGAVG 526_ VSFMF 531_ NGTSL 536_ GFVNS 541_ HLTSG 546_ SEKKL 551_ RRNQN 556_ YMNIL 561_ RFLAL 566_ GDKKL 571_ SPFNI 576_ THRFT 581_ HLFWF 586_ GDLNY 591_ RVDLP 596_ TWEAE 601_ TIIQK 606_ IKQQQ 611_ YADLL 616_ SHDQL 621_ LTERR 626_ EQKVF 631_ LHFEE 636_ EEITF 641_ APTYR 646_ FERLT 651_ RDKYA 656_ YTKQK 661_ ATGMK 666_ YNLPS 671_ WCDRV 676_ LWKSY 681_ PLVHV 686_ VCQSY 691_ GSTSD 696_ IMTSD 701_ HSPVF 706_ ATFEA 711_ GVTSQ 716_ FVSKN 721_ GPGTV 726_ DSQGQ 731_ IEFLR 736_ CYATL 741_ KTKSQ 746_ TKFYL 751_ EFHSS 756_ CLESF 761_ VKSQE 766_ GENEE 771_ GSEGE 776_ LVVKF 781_ GETLP 786_ KLKPI 791_ ISDPE 796_ YLLDQ 801_ HILIS 806_ IKSSD 811_ SDESY 816_ GEGCI 821_ ALRLE 826_ ATETQ 831_ LPIYT 836_ PLTHH 841_ GELTG 846_ HFQGE 851_ IKLQT 856_ SQGKT 861_ REKLY 866_ DFVKT 871_ ERDES 876_ SGPKT 881_ LKSLT 886_ SHDPM 891_ KQWEV 896_ TSRAP 901_ PCSGS 906_ SITEI 911_ INPNY 916_ MGVGP 921_ FGPPM 926_ PLHVK 931_ QTLSP 936_ DQQPT 941_ AWSYD 946_ QPPKD 951_ SPLGP 956_ CRGES 961_ PPTPP 966_ GQPPI 971_ SPKKF 976_ LPSTA 981_ NRGLP 986_ PRTQE 991_ SRPSD 996_ LGKNA 1001_ GDTLP 1006_ QEDLP 1011_ LTKPE 1016_ MFENP 1021_ LYGSL 1026_ SSFPK 1031_ PAPRK 1036_ DQESP 1041_ KMPRK 1046_ EPPPC 1051_ PEPGI 1056_ LSPSI 1061_ VLTKA 1066_ QEADR 1071_ GEGPG 1076_ KQVPA 1081_ PRLRS 1086_ FTCSS 1091_ SAEGR 1096_ AAGGD 1101_ KSQGK 1106_ PKTPV 1111_ SSQAP 1116_ VPAKR 1121_ PIKPS 1126_ RSEIN 1131_ QQTPP 1136_ TPTPR 1141_ PPLPV 1146_ KSPAV 1151_ LHLQH 1156_ SKGRD 1161_ YRDNT 1166_ ELPHH 1171_ GKHRP 1176_ EEGPP 1181_GPLGR
1: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression