Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]
1_MGYPE 6_ VERRE 11_ LLPAA 16_ APRER 21_ GSQGC 26_ GCGGA 31_ PARAG 36_ EGNSC 41_ LLFLG 46_ FFGLS 51_ LALHL 56_ LTLCC 61_ YLELR 66_ SELRR 71_ ERGAE 76_ SRLGG 81_ SGTPG 86_ TSGTL 91_ SSLGG 96_ LDPDS 101_ PITSH 106_ LGQPS 111_ PKQQP 116_ LEPGE 121_ AALHS 126_ DSQDG 131_ HQMAL 136_ LNFFF 141_ PDEKP 146_ YSEEE 151_ SRRVR 156_ RNKRS 161_ KSNEG 166_ ADGPV 171_ KNKKK 176_ GKKAG 181_ PPGPN 186_ GPPGP 191_ PGPPG 196_ PQGPP 201_ GIPGI 206_ PGIPG 211_ TTVMG 216_ PPGPP 221_ GPPGP 226_ QGPPG 231_ LQGPS 236_ GAADK 241_ AGTRE 246_ NQPAV 251_ VHLQG 256_ QGSAI 261_ QVKND 266_ LSGGV 271_ LNDWS 276_ RITMN 281_ PKVFK 286_ LHPRS 291_ GELEV 296_ LVDGT 301_ YFIYS 306_ QVEVY 311_ YINFT 316_ DFASY 321_ EVVVD 326_ EKPFL 331_ QCTRS 336_ IETGK 341_ TNYNT 346_ CYTAG 351_ VCLLK 356_ ARQKI 361_ AVKMV 366_ HADIS 371_ INMSK 376_ HTTFF 381_ GAIRL 386_GEAPA
1: Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:11039935, PubMed:27144394, PubMed:34582123, PubMed:8696334). May also play a role in cell adhesion (By similarity)
2: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R
3: Binds only to the receptor EDA2R