Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1)
1_MRQQD 6_ APKPT 11_ PAACR 16_ CSGLA 21_ RRVLT 26_ IAFAL 31_ LILGL 36_ MTWAY 41_ AAGVP 46_ LASDR 51_ YGLLA 56_ FGLYG 61_ AFLSA 66_ HLVAQ 71_ SLFAY 76_ LEHRR 81_ VAAAA 86_ RGPLD 91_ AATAR 96_ SVALT 101_ ISAYQ 106_ EDPAY 111_ LRQCL 116_ ASARA 121_ LLYPR 126_ ARLRV 131_ LMVVD 136_ GNRAE 141_ DLYMV 146_ DMFRE 151_ VFADE 156_ DPATY 161_ VWDGN 166_ YHQPW 171_ EPAAA 176_ GAVGA 181_ GAYRE 186_ VEAED 191_ PGRLA 196_ VEALV 201_ RTRRC 206_ VCVAQ 211_ RWGGK 216_ REVMY 221_ TAFKA 226_ LGDSV 231_ DYVQV 236_ CDSDT 241_ RLDPM 246_ ALLEL 251_ VRVLD 256_ EDPRV 261_ GAVGG 266_ DVRIL 271_ NPLDS 276_ WVSFL 281_ SSLRY 286_ WVAFN 291_ VERAC 296_ QSYFH 301_ CVSCI 306_ SGPLG 311_ LYRNN 316_ LLQQF 321_ LEAWY 326_ NQKFL 331_ GTHCT 336_ FGDDR 341_ HLTNR 346_ MLSMG 351_ YATKY 356_ TSRSR 361_ CYSET 366_ PSSFL 371_ RWLSQ 376_ QTRWS 381_ KSYFR 386_ EWLYN 391_ ALWWH 396_ RHHAW 401_ MTYEA 406_ VVSGL 411_ FPFFV 416_ AATVL 421_ RLFYA 426_ GRPWA 431_ LLWVL 436_ LCVQG 441_ VALAK 446_ AAFAA 451_ WLRGC 456_ LRMVL 461_ LSLYA 466_ PLYMC 471_ GLLPA 476_ KFLAL 481_ VTMNQ 486_ SGWGT 491_ SGRRK 496_ LAANY 501_ VPLLP 506_ LALWA 511_ LLLLG 516_ GLVRS 521_ VAHEA 526_ RADWS 531_ GPSRA 536_ AEAYH 541_ LAAGA 546_ GAYVG 551_ YWVAM 556_ LTLYW 561_ VGVRR 566_ LCRRR 571_TGGYR
1: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity)