TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)
1_MDKNI 6_ GEQLN 11_ KAYEA 16_ FRQAC 21_ MDRDS 26_ AVKEL 31_ QQKTE 36_ NYEQR 41_ IREQQ 46_ EQLSL 51_ QQTII 56_ DKLKS 61_ QLLLV 66_ NSTQD 71_ NNYGC 76_ VPLLE 81_ DSETR 86_ KNNLT 91_ LDQPQ 96_ DKVIS 101_ GIARE 106_ KLPKV 111_ RRQEV 116_ SSPRK 121_ ETSAR 126_ SLGSP 131_ LLHER 136_ GNIEK 141_ TFWDL 146_ KEEFH 151_ KICML 156_ AKAQK 161_ DHLSK 166_ LNIPD 171_ TATET 176_ QCSVP 181_ IQCTD 186_ KTDKQ 191_ EALFK 196_ PQAKD 201_ DINRG 206_ APSIT 211_ SVTPR 216_ GLCRD 221_ EEDTS 226_ FESLS 231_ KFNVK 236_ FPPMD 241_ NDSTF 246_ LHSTP 251_ ERPGI 256_ LSPAT 261_ SEAVC 266_ QEKFN 271_ MEFRD 276_ NPGNF 281_ VKTEE 286_ TLFEI 291_ QGIDP 296_ IASAI 301_ QNLKT 306_ TDKTK 311_ PSNLV 316_ NTCIR 321_ TTLDR 326_ AACLP 331_ PGDHN 336_ ALYVN 341_ SFPLL 346_ DPSDA 351_ PFPSL 356_ DSPGK 361_ AIRGP 366_ QQPIW 371_ KPFPN 376_ QDSDS 381_ VVLSG 386_ TDSEL 391_ HIPRV 396_ CEFCQ 401_ AVFPP 406_ SITSR 411_ GDFLR 416_HLNSH
1: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2