Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
1_MKSQG 6_ QHWYS 11_ SSDKN 16_ CKVSF 21_ REKLL 26_ IIDSN 31_ LGVQD 36_ VENLK 41_ FLCIG 46_ LVPNK 51_ KLEKS 56_ SSASD 61_ VFEHL 66_ LAEDL 71_ LSEED 76_ PFFLA 81_ ELLYI 86_ IRQKK 91_ LLQHL 96_ NCTKE 101_ EVERL 106_ LPTRQ 111_ RVSLF 116_ RNLLY 121_ ELSEG 126_ IDSEN 131_ LKDMI 136_ FLLKD 141_ SLPKT 146_ EMTSL 151_ SFLAF 156_ LEKQG 161_ KIDED 166_ NLTCL 171_ EDLCK 176_ TVVPK 181_ LLRNI 186_ EKYKR 191_ EKAIQ 196_ IVTPP 201_ VDKEA 206_ ESYQG 211_ EEELV 216_ SQTDV 221_ KTFLE 226_ ALPQE 231_ SWQNK 236_ HAGSN 241_ GNRAT 246_ NGAPS 251_ LVSRG 256_ MQGAS 261_ ANTLN 266_ SETST 271_ KRAAV 276_ YRMNR 281_ NHRGL 286_ CVIVN 291_ NHSFT 296_ SLKDR 301_ QGTHK 306_ DAEIL 311_ SHVFQ 316_ WLGFT 321_ VHIHN 326_ NVTKV 331_ EMEMV 336_ LQKQK 341_ CNPAH 346_ ADGDC 351_ FVFCI 356_ LTHGR 361_ FGAVY 366_ SSDEA 371_ LIPIR 376_ EIMSH 381_ FTALQ 386_ CPRLA 391_ EKPKL 396_ FFIQA 401_ CQGEE 406_ IQPSV 411_ SIEAD 416_ ALNPE 421_ QAPTS 426_ LQDSI 431_ PAEAD 436_ FLLGL 441_ ATVPG 446_ YVSFR 451_ HVEEG 456_ SWYIQ 461_ SLCNH 466_ LKKLV 471_ PRMLK 476_ FLEKT 481_ MEIRG 486_ RKRTV 491_ WGAKQ 496_ ISATS 501_ LPTAI 506_ SAQTP 511_ RPPMR 516_RWSSV
1: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC
2: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis
3: Isoform C is proteolytically inactive