Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)
1_MRMCT 6_ PIRGL 11_ LMALA 16_ VMFGT 21_ AMAFA 26_ PIPRI 31_ TWEHR 36_ EVHLV 41_ QFHEP 46_ DIYNY 51_ SALLL 56_ SEDKD 61_ TLYIG 66_ AREAV 71_ FAVNA 76_ LNISE 81_ KQHEV 86_ YWKVS 91_ EDKKA 96_ KCAEK 101_ GKSKQ 106_ TECLN 111_ YIRVL 116_ QPLSA 121_ TSLYV 126_ CGTNA 131_ FQPAC 136_ DHLNL 141_ TSFKF 146_ LGKNE 151_ DGKGR 156_ CPFDP 161_ AHSYT 166_ SVMVD 171_ GELYS 176_ GTSYN 181_ FLGSE 186_ PIISR 191_ NSSHS 196_ PLRTE 201_ YAIPW 206_ LNEPS 211_ FVFAD 216_ VIRKS 221_ PDSPD 226_ GEDDR 231_ VYFFF 236_ TEVSV 241_ EYEFV 246_ FRVLI 251_ PRIAR 256_ VCKGD 261_ QGGLR 266_ TLQKK 271_ WTSFL 276_ KARLI 281_ CSRPD 286_ SGLVF 291_ NVLRD 296_ VFVLR 301_ SPGLK 306_ VPVFY 311_ ALFTP 316_ QLNNV 321_ GLSAV 326_ CAYNL 331_ STAEE 336_ VFSHG 341_ KYMQS 346_ TTVEQ 351_ SHTKW 356_ VRYNG 361_ PVPKP 366_ RPGAC 371_ IDSEA 376_ RAANY 381_ TSSLN 386_ LPDKT 391_ LQFVK 396_ DHPLM 401_ DDSVT 406_ PIDNR 411_ PRLIK 416_ KDVNY 421_ TQIVV 426_ DRTQA 431_ LDGTV 436_ YDVMF 441_ VSTDR 446_ GALHK 451_ AISLE 456_ HAVHI 461_ IEETQ 466_ LFQDF 471_ EPVQT 476_ LLLSS 481_ KKGNR 486_ FVYAG 491_ SNSGV 496_ VQAPL 501_ AFCGK 506_ HGTCE 511_ DCVLA 516_ RDPYC 521_ AWSPP 526_ TATCV 531_ ALHQT 536_ ESPSR 541_ GLIQE 546_ MSGDA 551_ SVCPD 556_ KSKGS 561_ YRQHF 566_ FKHGG 571_ TAELK 576_ CSQKS 581_ NLARV 586_ FWKFQ 591_ NGVLK 596_ AESPK 601_ YGLMG 606_ RKNLL 611_ IFNLS 616_ EGDSG 621_ VYQCL 626_ SEERV 631_ KNKTV 636_ FQVVA 641_ KHVLE 646_ VKVVP 651_ KPVVA 656_ PTLSV 661_ VQTEG 666_ SRIAT 671_ KVLVA 676_ STQGS 681_ SPPTP 686_ AVQAT 691_ SSGAI 696_ TLPPK 701_ PAPTG 706_ TSCEP 711_ KIVIN 716_ TVPQL 721_ HSEKT 726_ MYLKS 731_ SDNRL 736_ LMSLF 741_ LFFFV 746_ LFLCL 751_ FFYNC 756_ YKGYL 761_ PRQCL 766_ KFRSA 771_ LLIGK 776_ KKPKS 781_ DFCDR 786_ EQSLK 791_ ETLVE 796_ PGSFS 801_ QQNGE 806_ HPKPA 811_ LDTGY 816_ ETEQD 821_ TITSK 826_ VPTDR 831_ EDSQR 836_ IDDLS 841_ ARDKP 846_ FDVKC 851_ ELKFA 856_DSDAD
1: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703)