DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
1_MSRIE 6_ KMSIL 11_ GVRSF 16_ GIEDK 21_ DKQII 26_ TFFSP 31_ LTILV 36_ GPNGA 41_ GKTTI 46_ IECLK 51_ YICTG 56_ DFPPG 61_ TKGNT 66_ FVHDP 71_ KVAQE 76_ TDVRA 81_ QIRLQ 86_ FRDVN 91_ GELIA 96_ VQRSM 101_ VCTQK 106_ SKKTE 111_ FKTLE 116_ GVITR 121_ TKHGE 126_ KVSLS 131_ SKCAE 136_ IDREM 141_ ISSLG 146_ VSKAV 151_ LNNVI 156_ FCHQE 161_ DSNWP 166_ LSEGK 171_ ALKQK 176_ FDEIF 181_ SATRY 186_ IKALE 191_ TLRQV 196_ RQTQG 201_ QKVKE 206_ YQMEL 211_ KYLKQ 216_ YKEKA 221_ CEIRD 226_ QITSK 231_ EAQLT 236_ SSKEI 241_ VKSYE 246_ NELDP 251_ LKNRL 256_ KEIEH 261_ NLSKI 266_ MKLDN 271_ EIKAL 276_ DSRKK 281_ QMEKD 286_ NSELE 291_ EKMEK 296_ VFQGT 301_ DEQLN 306_ DLYHN 311_ HQRTV 316_ REKER 321_ KLVDC 326_ HRELE 331_ KLNKE 336_ SRLLN 341_ QEKSE 346_ LLVEQ 351_ GRLQL 356_ QADRH 361_ QEHIR 366_ ARDSL 371_ IQSLA 376_ TQLEL 381_ DGFER 386_ GPFSE 391_ RQIKN 396_ FHKLV 401_ RERQE 406_ GEAKT 411_ ANQLM 416_ NDFAE 421_ KETLK 426_ QKQID 431_ EIRDK 436_ KTGLG 441_ RIIEL 446_ KSEIL 451_ SKKQN 456_ ELKNV 461_ KYELQ 466_ QLEGS 471_ SDRIL 476_ ELDQE 481_ LIKAE 486_ RELSK 491_ AEKNS 496_ NVETL 501_ KMEVI 506_ SLQNE 511_ KADLD 516_ RTLRK 521_ LDQEM 526_ EQLNH 531_ HTTTR 536_ TQMEM 541_ LTKDK 546_ ADKDE 551_ QIRKI 556_ KSRHS 561_ DELTS 566_ LLGYF 571_ PNKKQ 576_ LEDWL 581_ HSKSK 586_ EINQT 591_ RDRLA 596_ KLNKE 601_ LASSE 606_ QNKNH 611_ INNEL 616_ KRKEE 621_ QLSSY 626_ EDKLF 631_ DVCGS 636_ QDFES 641_ DLDRL 646_ KEEIE 651_ KSSKQ 656_ RAMLA 661_ GATAV 666_ YSQFI 671_ TQLTD 676_ ENQSC 681_ CPVCQ 686_ RVFQT 691_ EAELQ 696_ EVISD 701_ LQSKL 706_ RLAPD 711_ KLKST 716_ ESELK 721_ KKEKR 726_ RDEML 731_ GLVPM 736_ RQSII 741_ DLKEK 746_ EIPEL 751_ RNKLQ 756_ NVNRD 761_ IQRLK 766_ NDIEE 771_ QETLL 776_ GTIMP 781_ EEESA 786_ KVCLT 791_ DVTIM 796_ ERFQM 801_ ELKDV 806_ ERKIA 811_ QQAAK 816_ LQGID 821_ LDRTV 826_ QQVNQ 831_ EKQEK 836_ QHKLD 841_ TVSSK 846_ IELNR 851_ KLIQD 856_ QQEQI 861_ QHLKS 866_ TTNEL 871_ KSEKL 876_ QISTN 881_ LQRRQ 886_ QLEEQ 891_ TVELS 896_ TEVQS 901_ LYREI 906_ KDAKE 911_ QVSPL 916_ ETTLE 921_ KFQQE 926_ KEELI 931_ NKKNT 936_ SNKIA 941_ QDKLN 946_ DIKEK 951_ VKNIH 956_ GYMKD 961_ IENYI 966_ QDGKD 971_ DYKKQ 976_ KETEL 981_ NKVIA 986_ QLSEC 991_ EKHKE 996_ KINED 1001_ MRLMR 1006_ QDIDT 1011_ QKIQE 1016_ RWLQD 1021_ NLTLR 1026_ KRNEE 1031_ LKEVE 1036_ EERKQ 1041_ HLKEM 1046_ GQMQV 1051_ LQMKS 1056_ EHQKL 1061_ EENID 1066_ NIKRN 1071_ HNLAL 1076_ GRQKG 1081_ YEEEI 1086_ IHFKK 1091_ ELREP 1096_ QFRDA 1101_ EEKYR 1106_ EMMIV 1111_ MRTTE 1116_ LVNKD 1121_ LDIYY 1126_ KTLDQ 1131_ AIMKF 1136_ HSMKM 1141_ EEINK 1146_ IIRDL 1151_ WRSTY 1156_ RGQDI 1161_ EYIEI 1166_ RSDAD 1171_ ENVSA 1176_ SDKRR 1181_ NYNYR 1186_ VVMLK 1191_ GDTAL 1196_ DMRGR 1201_ CSAGQ 1206_ KVLAS 1211_ LIIRL 1216_ ALAET 1221_ FCLNC 1226_ GIIAL 1231_ DEPTT 1236_ NLDRE 1241_ NIESL 1246_ AHALV 1251_ EIIKS 1256_ RSQQR 1261_ NFQLL 1266_ VITHD 1271_ EDFVE 1276_ LLGRS 1281_ EYVEK 1286_ FYRIK 1291_ KNIDQ 1296_ CSEIV 1301_ KCSVS 1306_SLGFN
1: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888)