CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2)
1_MNGTL 6_ DHPDQ 11_ PDLDA 16_ IKMFV 21_ GQVPR 26_ TWSEK 31_ DLREL 36_ FEQYG 41_ AVYEI 46_ NVLRD 51_ RSQNP 56_ PQSKG 61_ CCFVT 66_ FYTRK 71_ AALEA 76_ QNALH 81_ NMKVL 86_ PGMHH 91_ PIQMK 96_ PADSE 101_ KNNAV 106_ EDRKL 111_ FIGMI 116_ SKKCT 121_ ENDIR 126_ VMFSS 131_ FGQIE 136_ ECRIL 141_ RGPDG 146_ LSRGC 151_ AFVTF 156_ TTRAM 161_ AQTAI 166_ KAMHQ 171_ AQTME 176_ GCSSP 181_ MVVKF 186_ ADTQK 191_ DKEQK 196_ RMAQQ 201_ LQQQM 206_ QQISA 211_ ASVWG 216_ NLAGL 221_ NTLGP 226_ QYLAL 231_ YLQLL 236_ QQTAS 241_ SGNLN 246_ TLSSL 251_ HPMGG 256_ LNAMQ 261_ LQNLA 266_ ALAAA 271_ ASAAQ 276_ NTPSG 281_ TNALT 286_ TSSSP 291_ LSVLT 296_ SSGSS 301_ PSSSS 306_ SNSVN 311_ PIASL 316_ GALQT 321_ LAGAT 326_ AGLNV 331_ GSLAG 336_ MAALN 341_ GGLGS 346_ SGLSN 351_ GTGST 356_ MEALT 361_ QAYSG 366_ IQQYA 371_ AAALP 376_ TLYNQ 381_ NLLTQ 386_ QSIGA 391_ AGSQK 396_ EGPEG 401_ ANLFI 406_ YHLPQ 411_ EFGDQ 416_ DLLQM 421_ FMPFG 426_ NVVSA 431_ KVFID 436_ KQTNL 441_ SKCFG 446_ FVSYD 451_ NPVSA 456_ QAAIQ 461_ SMNGF 466_ QIGMK 471_ RLKVQ 476_ LKRSK 481_NDSKP
1: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233)