ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)
1_MLEKF 6_ CNSTF 11_ WNSSF 16_ LDSPE 21_ ADLPL 26_ CFEQT 31_ VLVWI 36_ PLGYL 41_ WLLAP 46_ WQLLH 51_ VYKSR 56_ TKRSS 61_ TTKLY 66_ LAKQV 71_ FVGFL 76_ LILAA 81_ IELAL 86_ VLTED 91_ SGQAT 96_ VPAVR 101_ YTNPS 106_ LYLGT 111_ WLLVL 116_ LIQYS 121_ RQWCV 126_ QKNSW 131_ FLSLF 136_ WILSI 141_ LCGTF 146_ QFQTL 151_ IRTLL 156_ QGDNS 161_ NLAYS 166_ CLFFI 171_ SYGFQ 176_ ILILI 181_ FSAFS 186_ ENNES 191_ SNNPS 196_ SIASF 201_ LSSIT 206_ YSWYD 211_ SIILK 216_ GYKRP 221_ LTLED 226_ VWEVD 231_ EEMKT 236_ KTLVS 241_ KFETH 246_ MKREL 251_ QKARR 256_ ALQRR 261_ QEKSS 266_ QQNSG 271_ ARLPG 276_ LNKNQ 281_ SQSQD 286_ ALVLE 291_ DVEKK 296_ KKKSG 301_ TKKDV 306_ PKSWL 311_ MKALF 316_ KTFYM 321_ VLLKS 326_ FLLKL 331_ VNDIF 336_ TFVSP 341_ QLLKL 346_ LISFA 351_ SDRDT 356_ YLWIG 361_ YLCAI 366_ LLFTA 371_ ALIQS 376_ FCLQC 381_ YFQLC 386_ FKLGV 391_ KVRTA 396_ IMASV 401_ YKKAL 406_ TLSNL 411_ ARKEY 416_ TVGET 421_ VNLMS 426_ VDAQK 431_ LMDVT 436_ NFMHM 441_ LWSSV 446_ LQIVL 451_ SIFFL 456_ WRELG 461_ PSVLA 466_ GVGVM 471_ VLVIP 476_ INAIL 481_ STKSK 486_ TIQVK 491_ NMKNK 496_ DKRLK 501_ IMNEI 506_ LSGIK 511_ ILKYF 516_ AWEPS 521_ FRDQV 526_ QNLRK 531_ KELKN 536_ LLAFS 541_ QLQCV 546_ VIFVF 551_ QLTPV 556_ LVSVV 561_ TFSVY 566_ VLVDS 571_ NNILD 576_ AQKAF 581_ TSITL 586_ FNILR 591_ FPLSM 596_ LPMMI 601_ SSMLQ 606_ ASVST 611_ ERLEK 616_ YLGGD 621_ DLDTS 626_ AIRHD 631_ CNFDK 636_ AMQFS 641_ EASFT 646_ WEHDS 651_ EATVR 656_ DVNLD 661_ IMAGQ 666_ LVAVI 671_ GPVGS 676_ GKSSL 681_ ISAML 686_ GEMEN 691_ VHGHI 696_ TIKGT 701_ TAYVP 706_ QQSWI 711_ QNGTI 716_ KDNIL 721_ FGTEF 726_ NEKRY 731_ QQVLE 736_ ACALL 741_ PDLEM 746_ LPGGD 751_ LAEIG 756_ EKGIN 761_ LSGGQ 766_ KQRIS 771_ LARAT 776_ YQNLD 781_ IYLLD 786_ DPLSA 791_ VDAHV 796_ GKHIF 801_ NKVLG 806_ PNGLL 811_ KGKTR 816_ LLVTH 821_ SMHFL 826_ PQVDE 831_ IVVLG 836_ NGTIV 841_ EKGSY 846_ SALLA 851_ KKGEF 856_ AKNLK 861_ TFLRH 866_ TGPEE 871_ EATVH 876_ DGSEE 881_ EDDDY 886_ GLISS 891_ VEEIP 896_ EDAAS 901_ ITMRR 906_ ENSFR 911_ RTLSR 916_ SSRSN 921_ GRHLK 926_ SLRNS 931_ LKTRN 936_ VNSLK 941_ EDEEL 946_ VKGQK 951_ LIKKE 956_ FIETG 961_ KVKFS 966_ IYLEY 971_ LQAIG 976_ LFSIF 981_ FIILA 986_ FVMNS 991_ VAFIG 996_ SNLWL 1001_ SAWTS 1006_ DSKIF 1011_ NSTDY 1016_ PASQR 1021_ DMRVG 1026_ VYGAL 1031_ GLAQG 1036_ IFVFI 1041_ AHFWS 1046_ AFGFV 1051_ HASNI 1056_ LHKQL 1061_ LNNIL 1066_ RAPMR 1071_ FFDTT 1076_ PTGRI 1081_ VNRFA 1086_ GDIST 1091_ VDDTL 1096_ PQSLR 1101_ SWITC 1106_ FLGII 1111_ STLVM 1116_ ICMAT 1121_ PVFTI 1126_ IVIPL 1131_ GIIYV 1136_ SVQMF 1141_ YVSTS 1146_ RQLRR 1151_ LDSVT 1156_ RSPIY 1161_ SHFSE 1166_ TVSGL 1171_ PVIRA 1176_ FEHQQ 1181_ RFLKH 1186_ NEVRI 1191_ DTNQK 1196_ CVFSW 1201_ ITSNR 1206_ WLAIR 1211_ LELVG 1216_ NLTVF 1221_ FSALM 1226_ MVIYR 1231_ DTLSG 1236_ DTVGF 1241_ VLSNA 1246_ LNITQ 1251_ TLNWL 1256_ VRMTS 1261_ EIETN 1266_ IVAVE 1271_ RITEY 1276_ TKVEN 1281_ EAPWV 1286_ TDKRP 1291_ PPDWP 1296_ SKGKI 1301_ QFNNY 1306_ QVRYR 1311_ PELDL 1316_ VLRGI 1321_ TCDIG 1326_ SMEKI 1331_ GVVGR 1336_ TGAGK 1341_ SSLTN 1346_ CLFRI 1351_ LEAAG 1356_ GQIII 1361_ DGVDI 1366_ ASIGL 1371_ HDLRE 1376_ KLTII 1381_ PQDPI 1386_ LFSGS 1391_ LRMNL 1396_ DPFNN 1401_ YSDEE 1406_ IWKAL 1411_ ELAHL 1416_ KSFVA 1421_ SLQLG 1426_ LSHEV 1431_ TEAGG 1436_ NLSIG 1441_ QRQLL 1446_ CLGRA 1451_ LLRKS 1456_ KILVL 1461_ DEATA 1466_ AVDLE 1471_ TDNLI 1476_ QTTIQ 1481_ NEFAH 1486_ CTVIT 1491_ IAHRL 1496_ HTIMD 1501_ SDKVM 1506_ VLDNG 1511_ KIIEC 1516_ GSPEE 1521_ LLQIP 1526_ GPFYF 1531_ MAKEA 1536_GIENV
1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505)