Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
1_MEDFA 6_ RGAAS 11_ PGPSR 16_ PGLVP 21_ VSIIG 26_ AEDED 31_ FENEL 36_ ETNSE 41_ EQNSQ 46_ FQSLE 51_ QVKRR 56_ PAHLM 61_ ALLQH 66_ VALQF 71_ EPGPL 76_ LCCLH 81_ ADMLG 86_ SLGPK 91_ EAKKA 96_ FLDFY 101_ HSFLE 106_ KTAVL 111_ RVPVP 116_ PNVAF 121_ ELDRT 126_ RADLI 131_ SEDVQ 136_ RRFVQ 141_ EVVQS 146_ QQVAV 151_ GRQLE 156_ DFRSK 161_ RLMGM 166_ TPWEQ 171_ ELAQL 176_ EAWVG 181_ RDRAS 186_ YEARE 191_ RHVAE 196_ RLLMH 201_ LEEMQ 206_ HTIST 211_ DEEKS 216_ AAVVN 221_ AIGLY 226_ MRHLG 231_ VRTKS 236_ GDKKS 241_ GRNFF 246_ RKKVM 251_ GNRRS 256_ DEPAK 261_ TKKGL 266_ SSILD 271_ AARWN 276_ RGEPQ 281_ VPDFR 286_ HLKAE 291_ VDAEK 296_ PGATD 301_ RKGGV 306_ GMPSR 311_ DRNIG 316_ APGQD 321_ TPGVS 326_ LHPLS 331_ LDSPD 336_ REPGA 341_ DAPLE 346_ LGDSS 351_ PQGPM 356_ SLESL 361_ APPES 366_ TDEGA 371_ ETESP 376_ EPGDE 381_ GEPGR 386_ SGLEL 391_ EPEEP 396_ PGWRE 401_ LVPPD 406_ TLHSL 411_ PKSQV 416_ KRQEV 421_ ISELL 426_ VTEAA 431_ HVRML 436_ RVLHD 441_ LFFQP 446_ MAECL 451_ FFPLE 456_ ELQNI 461_ FPSLD 466_ ELIEV 471_ HSLFL 476_ DRLMK 481_ RRQES 486_ GYLIE 491_ EIGDV 496_ LLARF 501_ DGAEG 506_ SWFQK 511_ ISSRF 516_ CSRQS 521_ FALEQ 526_ LKAKQ 531_ RKDPR 536_ FCAFV 541_ QEAES 546_ RPRCR 551_ RLQLK 556_ DMIPT 561_ EMQRL 566_ TKYPL 571_ LLQSI 576_ GQNTE 581_ EPTER 586_ EKVEL 591_ AAECC 596_ REILH 601_ HVNQA 606_ VRDME 611_ DLLRL 616_ KDYQR 621_ RLDLS 626_ HLRQS 631_ SDPML 636_ SEFKN 641_ LDITK 646_ KKLVH 651_ EGPLT 656_ WRVTK 661_ DKAVE 666_ VHVLL 671_ LDDLL 676_ LLLQR 681_ QDERL 686_ LLKSH 691_ SRTLT 696_ PTPDG 701_ KTMLR 706_ PVLRL 711_ TSAMT 716_ REVAT 721_ DHKAF 726_ YVLFT 731_ WDQEA 736_ QIYEL 741_ VAQTV 746_ SERKN 751_ WCALI 756_ TETAG 761_ SLKVP 766_ APASR 771_ PKPRP 776_ SPSST 781_ REPLL 786_ SSSEN 791_ GNGGR 796_ ETSPA 801_ DARTE 806_ RILSD 811_ LLPFC 816_ RPGPE 821_ GQLAA 826_ TALRK 831_ VLSLK 836_ QLLFP 841_ AEEDN 846_ GAGPP 851_ RDGDG 856_ VPGGG 861_ PLSPA 866_ RTQEI 871_ QENLL 876_ SLEET 881_ MKQLE 886_ ELEEE 891_ FCRLR 896_ PLLSQ 901_ LGGNS 906_VPQPG
1: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche