Phosphatidate cytidylyltransferase 1 (EC 2.7.7.41) (CDP-DAG synthase 1) (CDP-DG synthase 1) (CDP-diacylglycerol synthase 1) (CDS 1) (CDP-diglyceride pyrophosphorylase 1) (CDP-diglyceride synthase 1) (CTP:phosphatidate cytidylyltransferase 1)
1_MLELR 6_ HRGSC 11_ PGPRE 16_ AVSPP 21_ HREGE 26_ AAGGD 31_ HETES 36_ TSDKE 41_ TDIDD 46_ RYGDL 51_ DSRTD 56_ SDIPE 61_ IPPSS 66_ DRTPE 71_ ILKKA 76_ LSGLS 81_ SRWKN 86_ WWIRG 91_ ILTLT 96_ MISLF 101_ FLIIY 106_ MGSFM 111_ LMLLV 116_ LGIQV 121_ KCFHE 126_ IITIG 131_ YRVYH 136_ SYDLP 141_ WFRTL 146_ SWYFL 151_ LCVNY 156_ FFYGE 161_ TVADY 166_ FATFV 171_ QREEQ 176_ LQFLI 181_ RYHRF 186_ ISFAL 191_ YLAGF 196_ CMFVL 201_ SLVKK 206_ HYRLQ 211_ FYMFA 216_ WTHVT 221_ LLITV 226_ TQSHL 231_ VIQNL 236_ FEGMI 241_ WFLVP 246_ ISSVI 251_ CNDIT 256_ AYLFG 261_ FFFGR 266_ TPLIK 271_ LSPKK 276_ TWEGF 281_ IGGFF 286_ STVVF 291_ GFIAA 296_ YVLSK 301_ YQYFV 306_ CPVEY 311_ RSDVN 316_ SFVTE 321_ CEPSE 326_ LFQLQ 331_ TYSLP 336_ PFLKA 341_ VLRQE 346_ RVSLY 351_ PFQIH 356_ SIALS 361_ TFASL 366_ IGPFG 371_ GFFAS 376_ GFKRA 381_ FKIKD 386_ FANTI 391_ PGHGG 396_ IMDRF 401_ DCQYL 406_ MATFV 411_ HVYIT 416_ SFIRG 421_ PNPSK 426_ VLQQL 431_ LVLQP 436_ EQQLN 441_ IYKTL 446_ KTHLI 451_ EKGIL 456_QPTLK
1: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833, PubMed:9407135). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity)