COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
1_MAASG 6_ SGMAQ 11_ KTWEL 16_ ANNMQ 21_ EAQSI 26_ DEIYK 31_ YDKKQ 36_ QQEIL 41_ AAKPW 46_ TKDHH 51_ YFKYC 56_ KISAL 61_ ALLKM 66_ VMHAR 71_ SGGNL 76_ EVMGL 81_ MLGKV 86_ DGETM 91_ IIMDS 96_ FALPV 101_ EGTET 106_ RVNAQ 111_ AAAYE 116_ YMAAY 121_ IENAK 126_ QVGRL 131_ ENAIG 136_ WYHSH 141_ PGYGC 146_ WLSGI 151_ DVSTQ 156_ MLNQQ 161_ FQEPF 166_ VAVVI 171_ DPTRT 176_ ISAGK 181_ VNLGA 186_ FRTYP 191_ KGYKP 196_ PDEGP 201_ SEYQT 206_ IPLNK 211_ IEDFG 216_ VHCKQ 221_ YYALE 226_ VSYFK 231_ SSLDR 236_ KLLEL 241_ LWNKY 246_ WVNTL 251_ SSSSL 256_ LTNAD 261_ YTTGQ 266_ VFDLS 271_ EKLEQ 276_ SEAQL 281_ GRGSF 286_ MLGLE 291_ THDRK 296_ SEDKL 301_ AKATR 306_ DSCKT 311_ TIEAI 316_ HGLMS 321_ QVIKD 326_KLFNQ
1: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2