Transcription factor GATA-6 (GATA-binding factor 6)
1_MALTD 6_ GGWCL 11_ PKRFG 16_ AAGAD 21_ ASDSR 26_ AFPAR 31_ EPSTP 36_ PSPIS 41_ SSSSS 46_ CSRGG 51_ ERGPG 56_ GASNC 61_ GTPQL 66_ DTEAA 71_ AGPPA 76_ RSLLL 81_ SSYAS 86_ HPFGA 91_ PHGPS 96_ APGVA 101_ GPGGN 106_ LSSWE 111_ DLLLF 116_ TDLDQ 121_ AATAS 126_ KLLWS 131_ SRGAK 136_ LSPFA 141_ PEQPE 146_ EMYQT 151_ LAALS 156_ SQGPA 161_ AYDGA 166_ PGGFV 171_ HSAAA 176_ AAAAA 181_ AAASS 186_ PVYVP 191_ TTRVG 196_ SMLPG 201_ LPYHL 206_ QGSGS 211_ GPANH 216_ AGGAG 221_ AHPGW 226_ PQASA 231_ DSPPY 236_ GSGGG 241_ AAGGG 246_ AAGPG 251_ GAGSA 256_ AAHVS 261_ ARFPY 266_ SPSPP 271_ MANGA 276_ AREPG 281_ GYAAA 286_ GSGGA 291_ GGVSG 296_ GGSSL 301_ AAMGG 306_ REPQY 311_ SSLSA 316_ ARPLN 321_ GTYHH 326_ HHHHH 331_ HHHPS 336_ PYSPY 341_ VGAPL 346_ TPAWP 351_ AGPFE 356_ TPVLH 361_ SLQSR 366_ AGAPL 371_ PVPRG 376_ PSADL 381_ LEDLS 386_ ESREC 391_ VNCGS 396_ IQTPL 401_ WRRDG 406_ TGHYL 411_ CNACG 416_ LYSKM 421_ NGLSR 426_ PLIKP 431_ QKRVP 436_ SSRRL 441_ GLSCA 446_ NCHTT 451_ TTTLW 456_ RRNAE 461_ GEPVC 466_ NACGL 471_ YMKLH 476_ GVPRP 481_ LAMKK 486_ EGIQT 491_ RKRKP 496_ KNINK 501_ SKTCS 506_ GNSNN 511_ SIPMT 516_ PTSTS 521_ SNSDD 526_ CSKNT 531_ SPTTQ 536_ PTASG 541_ AGAPV 546_ MTGAG 551_ ESTNP 556_ ENSEL 561_ KYSGQ 566_ DGLYI 571_ GVSLA 576_ SPAEV 581_ TSSVR 586_PDSWC
1: Transcriptional activator (PubMed:19666519, PubMed:22750565, PubMed:22824924, PubMed:27756709). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341)