Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
1_MDVVD 6_ PDIFN 11_ RDPRD 16_ HYDLL 21_ QRLGG 26_ GTYGE 31_ VFKAR 36_ DKVSG 41_ DLVAL 46_ KMVKM 51_ EPDDD 56_ VSTLQ 61_ KEILI 66_ LKTCR 71_ HANIV 76_ AYHGS 81_ YLWLQ 86_ KLWIC 91_ MEFCG 96_ AGSLQ 101_ DIYQV 106_ TGSLS 111_ ELQIS 116_ YVCRE 121_ VLQGL 126_ AYLHS 131_ QKKIH 136_ RDIKG 141_ ANILI 146_ NDAGE 151_ VRLAD 156_ FGISA 161_ QIGAT 166_ LARRL 171_ SFIGT 176_ PYWMA 181_ PEVAA 186_ VALKG 191_ GYNEL 196_ CDIWS 201_ LGITA 206_ IELAE 211_ LQPPL 216_ FDVHP 221_ LRVLF 226_ LMTKS 231_ GYQPP 236_ RLKEK 241_ GKWSA 246_ AFHNF 251_ IKVTL 256_ TKSPK 261_ KRPSA 266_ TKMLS 271_ HQLVS 276_ QPGLN 281_ RGLIL 286_ DLLDK 291_ LKNPG 296_ KGPSI 301_ GDIED 306_ EEPEL 311_ PPAIP 316_ RRIRS 321_ THRSS 326_ SLGIP 331_ DADCC 336_ RRHME 341_ FRKLR 346_ GMETR 351_ PPANT 356_ ARLQP 361_ PRDLR 366_ SSSPR 371_ KQLSE 376_ SSDDD 381_ YDDVD 386_ IPTPA 391_ EDTPP 396_ PLPPK 401_ PKFRS 406_ PSDEG 411_ PGSMG 416_ DDGQL 421_ SPGVL 426_ VRCAS 431_ GPPPN 436_ SPRPG 441_ PPPST 446_ SSPHL 451_ TAHSE 456_ PSLWN 461_ PPSRE 466_ LDKPP 471_ LLPPK 476_ KEKMK 481_ RKGCA 486_ LLVKL 491_ FNGCP 496_ LRIHS 501_ TAAWT 506_ HPSTK 511_ DQHLL 516_ LGAEE 521_ GIFIL 526_ NRNDQ 531_ EATLE 536_ MLFPS 541_ RTTWV 546_ YSINN 551_ VLMSL 556_ SGKTP 561_ HLYSH 566_ SILGL 571_ LERKE 576_ TRAGN 581_ PIAHI 586_ SPHRL 591_ LARKN 596_ MVSTK 601_ IQDTK 606_ GCRAC 611_ CVAEG 616_ ASSGG 621_ PFLCG 626_ ALETS 631_ VVLLQ 636_ WYQPM 641_ NKFLL 646_ VRQVL 651_ FPLPT 656_ PLSVF 661_ ALLTG 666_ PGSEL 671_ PAVCI 676_ GVSPG 681_ RPGKS 686_ VLFHT 691_ VRFGA 696_ LSCWL 701_ GEMST 706_ EHRGP 711_ VQVTQ 716_ VEEDM 721_ VMVLM 726_ DGSVK 731_ LVTPE 736_ GSPVR 741_ GLRTP 746_ EIPMT 751_ EAVEA 756_ VAMVG 761_ GQLQA 766_ FWKHG 771_ VQVWA 776_ LGSDQ 781_ LLQEL 786_ RDPTL 791_ TFRLL 796_ GSPRL 801_ ECSGT 806_ ISPHC 811_ NLLLP 816_ GSSNS 821_ PASAS 826_RVAGI
1: Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity)