Gene name: SMARCD2

Uniprot entry:

Q92925

Protein names:

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B)

Protein sequence:

1_MSGRG 6_ AGGFP 11_ LPPLS 16_ PGGGA 21_ VAAAL 26_ GAPPP 31_ PAGPG 36_ MLPGP 41_ ALRGP 46_ GPAGG 51_ VGGPG 56_ AAAFR 61_ PMGPA 66_ GPAAQ 71_ YQRPG 76_ MSPGN 81_ RMPMA 86_ GLQVG 91_ PPAGS 96_ PFGAA 101_ APLRP 106_ GMPPT 111_ MMDPF 116_ RKRLL 121_ VPQAQ 126_ PPMPA 131_ QRRGL 136_ KRRKM 141_ ADKVL 146_ PQRIR 151_ ELVPE 156_ SQAYM 161_ DLLAF 166_ ERKLD 171_ QTIAR 176_ KRMEI 181_ QEAIK 186_ KPLTQ 191_ KRKLR 196_ IYISN 201_ TFSPS 206_ KAEGD 211_ SAGTA 216_ GTPGG 221_ TPAGD 226_ KVASW 231_ ELRVE 236_ GKLLD 241_ DPSKQ 246_ KRKFS 251_ SFFKS 256_ LVIEL 261_ DKELY 266_ GPDNH 271_ LVEWH 276_ RMPTT 281_ QETDG 286_ FQVKR 291_ PGDLN 296_ VKCTL 301_ LLMLD 306_ HQPPQ 311_ YKLDP 316_ RLARL 321_ LGVHT 326_ QTRAA 331_ IMQAL 336_ WLYIK 341_ HNQLQ 346_ DGHER 351_ EYINC 356_ NRYFR 361_ QIFSC 366_ GRLRF 371_ SEIPM 376_ KLAGL 381_ LQHPD 386_ PIVIN 391_ HVISV 396_ DPNDQ 401_ KKTAC 406_ YDIDV 411_ EVDDP 416_ LKAQM 421_ SNFLA 426_ STTNQ 431_ QEIAS 436_ LDVKI 441_ HETIE 446_ SINQL 451_ KTQRD 456_ FMLSF 461_ STDPQ 466_ DFIQE 471_ WLRSQ 476_ RRDLK 481_ IITDV 486_ IGNPE 491_ EERRA 496_ AFYHQ 501_ PWAQE 506_ AVGRH 511_ IFAKV 516_ QQRRQ 521_ ELEQV 526_LGIRL

Protein annotations

Protein functions:

1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036)