Ras-related protein Rab-8B
1_MAKTY 6_ DYLFK 11_ LLLIG 16_ DSGVG 21_ KTCLL 26_ FRFSE 31_ DAFNT 36_ TFIST 41_ IGIDF 46_ KIRTI 51_ ELDGK 56_ KIKLQ 61_ IWDTA 66_ GQERF 71_ RTITT 76_ AYYRG 81_ AMGIM 86_ LVYDI 91_ TNEKS 96_ FDNIK 101_ NWIRN 106_ IEEHA 111_ SSDVE 116_ RMILG 121_ NKCDM 126_ NDKRQ 131_ VSKER 136_ GEKLA 141_ IDYGI 146_ KFLET 151_ SAKSS 156_ ANVEE 161_ AFFTL 166_ ARDIM 171_ TKLNR 176_ KMNDS 181_ NSAGA 186_ GGPVK 191_ ITENR 196_ SKKTS 201_FFRCS
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433)