Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
1_MGPPL 6_ PLLLL 11_ LLLLL 16_ PPRVL 21_ PAAPS 26_ SVPRG 31_ RQLPG 36_ RLGCL 41_ LEEGL 46_ CGASE 51_ ACVND 56_ GVFGR 61_ CQKVP 66_ AMDFY 71_ RYEVS 76_ PVALQ 81_ RLRVA 86_ LQKLS 91_ GTGFT 96_ WQDDY 101_ TQYVM 106_ DQELA 111_ DLPKT 116_ YLRRP 121_ EASSP 126_ ARPSK 131_ HSVGS 136_ ERRYS 141_ REGGA 146_ ALANA 151_ LRRHL 156_ PFLEA 161_ LSQAP 166_ ASDVL 171_ ARTHT 176_ AQDRP 181_ PAEGD 186_ DRFSE 191_ SILTY 196_ VAHTS 201_ ALTYP 206_ PGSRT 211_ QLRED 216_ LLPRT 221_ LGQLQ 226_ PDELS 231_ PKVDS 236_ GVDRH 241_ HLMAA 246_ LSAYA 251_ AQRPP 256_ APPGE 261_ GSLEP 266_ QYLLR 271_ APSRM 276_ PRPLL 281_ APAAP 286_ QKWPS 291_ PLGDS 296_ EDPSS 301_ TGDGA 306_ RIHTL 311_ LKDLQ 316_ RQPAE 321_ VRGLS 326_ GLELD 331_ GMAEL 336_ MAGLM 341_ QGVDH 346_ GVARG 351_ SPGRA 356_ ALGES 361_ GEQAD 366_ GPKAT 371_ LRGDS 376_ FPDDG 381_ VQDDD 386_ DRLYQ 391_ EVHRL 396_ SATLG 401_ GLLQD 406_ HGSRL 411_ LPGAL 416_ PFARP 421_ LDMER 426_ KKSEH 431_ PESSL 436_ SSEEE 441_ TAGVE 446_ NVKSQ 451_ TYSKD 456_ LLGQQ 461_ PHSEP 466_ GAAAF 471_ GELQN 476_ QMPGP 481_ SKEEQ 486_ SLPAG 491_ AQEAL 496_ SDGLQ 501_ LEVQP 506_ SEEEA 511_ RGYIV 516_ TDRDP 521_ LRPEE 526_ GRRLV 531_ EDVAR 536_ LLQVP 541_ SSAFA 546_ DVEVL 551_ GPAVT 556_ FKVSA 561_ NVQNV 566_ TTEDV 571_ EKATV 576_ DNKDK 581_ LEETS 586_ GLKIL 591_ QTGVG 596_ SKSKL 601_ KFLPP 606_ QAEQE 611_ DSTKF 616_ IALTL 621_ VSLAC 626_ ILGVL 631_ LASGL 636_ IYCLR 641_ HSSQH 646_ RLKEK 651_ LSGLG 656_ GDPGA 661_ DATAA 666_ YQELC 671_ RQRMA 676_ TRPPD 681_ RPEGP 686_ HTSRI 691_ SSVSS 696_ QFSDG 701_ PIPSP 706_ SARSS 711_ ASSWS 716_ EEPVQ 721_ SNMDI 726_ STGHM 731_ ILSYM 736_ EDHLK 741_ NKNRL 746_ EKEWE 751_ ALCAY 756_ QAEPN 761_ SSFVA 766_ QREEN 771_ VPKNR 776_ SLAVL 781_ TYDHS 786_ RVLLK 791_ AENSH 796_ SHSDY 801_ INASP 806_ IMDHD 811_ PRNPA 816_ YIATQ 821_ GPLPA 826_ TVADF 831_ WQMVW 836_ ESGCV 841_ VIVML 846_ TPLAE 851_ NGVRQ 856_ CYHYW 861_ PDEGS 866_ NLYHI 871_ YEVNL 876_ VSEHI 881_ WCEDF 886_ LVRSF 891_ YLKNL 896_ QTNET 901_ RTVTQ 906_ FHFLS 911_ WYDRG 916_ VPSSS 921_ RSLLD 926_ FRRKV 931_ NKCYR 936_ GRSCP 941_ IIVHC 946_ SDGAG 951_ RSGTY 956_ VLIDM 961_ VLNKM 966_ AKGAK 971_ EIDIA 976_ ATLEH 981_ LRDQR 986_ PGMVQ 991_ TKEQF 996_ EFALT 1001_ AVAEE 1006_VNAIL
1: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550)