Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
1_MFQIP 6_ EFEPS 11_ EQEDS 16_ SSAER 21_ GLGPS 26_ PAGDG 31_ PSGSG 36_ KHHRQ 41_ APGLL 46_ WDASH 51_ QQEQP 56_ TSSSH 61_ HGGAG 66_ AVEIR 71_ SRHSS 76_ YPAGT 81_ EDDEG 86_ MGEEP 91_ SPFRG 96_ RSRSA 101_ PPNLW 106_ AAQRY 111_ GRELR 116_ RMSDE 121_ FVDSF 126_ KKGLP 131_ RPKSA 136_ GTATQ 141_ MRQSS 146_ SWTRV 151_ FQSWW 156_ DRNLG 161_RGSSA
1: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways