Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1)
1_MNSHS 6_ YNGSV 11_ GRPLG 16_ SGPGA 21_ LGRDP 26_ PDPEA 31_ GHPPQ 36_ PPHSP 41_ GLQVV 46_ VAKSE 51_ PARPS 56_ PGSPR 61_ GQPQD 66_ QDDDE 71_ DDEED 76_ EAGRQ 81_ RASGK 86_ PSNVG 91_ HRLGH 96_ RRALF 101_ EKRKR 106_ LSDYA 111_ LIFGM 116_ FGIVV 121_ MVTET 126_ ELSWG 131_ VYTKE 136_ SLYSF 141_ ALKCL 146_ ISLST 151_ AILLG 156_ LVVLY 161_ HAREI 166_ QLFMV 171_ DNGAD 176_ DWRIA 181_ MTCER 186_ VFLIS 191_ LELAV 196_ CAIHP 201_ VPGHY 206_ RFTWT 211_ ARLAF 216_ TYAPS 221_ VAEAD 226_ VDVLL 231_ SIPMF 236_ LRLYL 241_ LGRVM 246_ LLHSK 251_ IFTDA 256_ SSRSI 261_ GALNK 266_ ITFNT 271_ RFVMK 276_ TLMTI 281_ CPGTV 286_ LLVFS 291_ ISSWI 296_ IAAWT 301_ VRVCE 306_ RYHDK 311_ QEVTS 316_ NFLGA 321_ MWLIS 326_ ITFLS 331_ IGYGD 336_ MVPHT 341_ YCGKG 346_ VCLLT 351_ GIMGA 356_ GCTAL 361_ VVAVV 366_ ARKLE 371_ LTKAE 376_ KHVHN 381_ FMMDT 386_ QLTKR 391_ VKNAA 396_ ANVLR 401_ ETWLI 406_ YKHTR 411_ LVKKP 416_ DQARV 421_ RKHQR 426_ KFLQA 431_ IHQAQ 436_ KLRSV 441_ KIEQG 446_ KLNDQ 451_ ANTLT 456_ DLAKT 461_ QTVMY 466_ DLVSE 471_ LHAQH 476_ EELEA 481_ RLATL 486_ ESRLD 491_ ALGAS 496_ LQALP 501_ GLIAQ 506_ AIRPP 511_ PPPLP 516_ PRPGP 521_ GPQDQ 526_ AARSS 531_ PCRWT 536_PVAPS
1: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:17142458, PubMed:8781233, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:8781233). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (Probable). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)