Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
1_MAEKA 6_ PPGLN 11_ RKTSR 16_ STLSL 21_ PPEPV 26_ DIIRS 31_ KTCSR 36_ RVKIN 41_ VGGLN 46_ HEVLW 51_ RTLDR 56_ LPRTR 61_ LGKLR 66_ DCNTH 71_ ESLLE 76_ VCDDY 81_ NLNEN 86_ EYFFD 91_ RHPGA 96_ FTSIL 101_ NFYRT 106_ GKLHM 111_ MEEMC 116_ ALSFG 121_ QELDY 126_ WGIDE 131_ IYLES 136_ CCQAR 141_ YHQKK 146_ EQMNE 151_ ELRRE 156_ AETMR 161_ EREGE 166_ EFDNT 171_ CCPDK 176_ RKKLW 181_ DLLEK 186_ PNSSV 191_ AAKIL 196_ AIVSI 201_ LFIVL 206_ STIAL 211_ SLNTL 216_ PELQE 221_ TDEFG 226_ QLNDN 231_ RQLAH 236_ VEAVC 241_ IAWFT 246_ MEYLL 251_ RFLSS 256_ PNKWK 261_ FFKGP 266_ LNVID 271_ LLAIL 276_ PYYVT 281_ IFLTE 286_ SNKSV 291_ LQFQN 296_ VRRVV 301_ QIFRI 306_ MRILR 311_ ILKLA 316_ RHSTG 321_ LQSLG 326_ FTLRR 331_ SYNEL 336_ GLLIL 341_ FLAMG 346_ IMIFS 351_ SLVFF 356_ AEKDE 361_ DATKF 366_ TSIPA 371_ SFWWA 376_ TITMT 381_ TVGYG 386_ DIYPK 391_ TLLGK 396_ IVGGL 401_ CCIAG 406_ VLVIA 411_ LPIPI 416_ IVNNF 421_ SEFYK 426_ EQKRQ 431_ EKAIK 436_ RREAL 441_ ERAKR 446_ NGSIV 451_ SMNLK 456_ DAFAR 461_ SMELI 466_ DVAVE 471_ KAGES 476_ ANTKD 481_ SADDN 486_ HLSPS 491_ RWKWA 496_ RKALS 501_ ETSSN 506_ KSFEN 511_ KYQEV 516_ SQKDS 521_ HEQLN 526_ NTSSS 531_ SPQHL 536_ SAQKL 541_ EMLYN 546_ EITKT 551_ QPHSH 556_ PNPDC 561_ QEKPE 566_ RPSAY 571_ EEEIE 576_ MEEVV 581_ CPQEQ 586_ LAVAQ 591_ TEVIV 596_ DMKST 601_ SSIDS 606_ FTSCA 611_ TDFTE 616_ TERSP 621_ LPPPS 626_ ASHLQ 631_ MKFPT 636_ DLPGT 641_ EEHQR 646_ ARGPP 651_ FLTLS 656_ REKGP 661_ AARDG 666_ TLEYA 671_ PVDIT 676_ VNLDA 681_ SGSQC 686_ GLHSP 691_ LQSDN 696_ ATDSP 701_ KSSLK 706_ GSNPL 711_ KSRSL 716_ KVNFK 721_ ENRGS 726_ APQTP 731_ PSTAR 736_ PLPVT 741_ TADFS 746_ LTTPQ 751_ HISTI 756_ LLEET 761_ PSQGD 766_ RPLLG 771_ TEVSA 776_ PCQGP 781_ SKGLS 786_ PRFPK 791_ QKLFP 796_ FSSRE 801_ RRSFT 806_ EIDTG 811_ DDEDF 816_ LELPG 821_ AREEK 826_ QVDSS 831_ PNCFA 836_ DKPSD 841_ GRDPL 846_ REEGS 851_ VGSSS 856_ PQDTG 861_ HNCRQ 866_ DIYHA 871_ VSEVK 876_ KDSSQ 881_ EGCKM 886_ ENHLF 891_ APEIH 896_ SNPGD 901_ TGYCP 906_TRETS
1: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells