GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)
1_MDSGT 6_ RPVGS 11_ CCSSP 16_ AGLSR 21_ EYKLV 26_ MLGAG 31_ GVGKS 36_ AMTMQ 41_ FISHR 46_ FPEDH 51_ DPTIE 56_ DAYKI 61_ RIRID 66_ DEPAN 71_ LDILD 76_ TAGQA 81_ EFTAM 86_ RDQYM 91_ RAGEG 96_ FIICY 101_ SITDR 106_ RSFHE 111_ VREFK 116_ QLIYR 121_ VRRTD 126_ DTPVV 131_ LVGNK 136_ SDLKQ 141_ LRQVT 146_ KEEGL 151_ ALARE 156_ FSCPF 161_ FETSA 166_ AYRYY 171_ IDDVF 176_ HALVR 181_ EIRRK 186_ EKEAV 191_ LAMEK 196_ KSKPK 201_ NSVWK 206_ RLKSP 211_FRKKK
1: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation