Peroxisomal membrane protein PEX13 (Peroxin-13)
1_MASQP 6_ PPPPK 11_ PWETR 16_ RIPGA 21_ GPGPG 26_ PGPTF 31_ QSADL 36_ GPTLM 41_ TRPGQ 46_ PALTR 51_ VPPPI 56_ LPRPS 61_ QQTGS 66_ SSVNT 71_ FRPAY 76_ SSFSS 81_ GYGAY 86_ GNSFY 91_ GGYSP 96_ YSYGY 101_ NGLGY 106_ NRLRV 111_ DDLPP 116_ SRFVQ 121_ QAEES 126_ SRGAF 131_ QSIES 136_ IVHAF 141_ ASVSM 146_ MMDAT 151_ FSAVY 156_ NSFRA 161_ VLDVA 166_ NHFSR 171_ LKIHF 176_ TKVFS 181_ AFALV 186_ RTIRY 191_ LYRRL 196_ QRMLG 201_ LRRGS 206_ ENEDL 211_ WAESE 216_ GTVAC 221_ LGAED 226_ RAATS 231_ AKSWP 236_ IFLFF 241_ AVILG 246_ GPYLI 251_ WKLLS 256_ THSDE 261_ VTDSI 266_ NWASG 271_ EDDHV 276_ VARAE 281_ YDFAA 286_ VSEEE 291_ ISFRA 296_ GDMLN 301_ LALKE 306_ QQPKV 311_ RGWLL 316_ ASLDG 321_ QTTGL 326_ IPANY 331_ VKILG 336_ KRKGR 341_ KTVES 346_ SKVSK 351_ QQQSF 356_ TNPTL 361_ TKGAT 366_ VADSL 371_ DEQEA 376_ AFESV 381_ FVETN 386_ KVPVA 391_ PDSIG 396_KDGEK
1: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:28765278, PubMed:8858165, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:28765278, PubMed:8858165, PubMed:9653144). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:8858165, PubMed:9653144)