Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
1_MVWDR 6_ QTKME 11_ YEWKP 16_ DEQGL 21_ QQILQ 26_ LLKES 31_ QSPDT 36_ TIQRT 41_ VQQKL 46_ EQLNQ 51_ YPDFN 56_ NYLIF 61_ VLTKL 66_ KSEDE 71_ PTRSL 76_ SGLIL 81_ KNNVK 86_ AHFQN 91_ FPNGV 96_ TDFIK 101_ SECLN 106_ NIGDS 111_ SPLIR 116_ ATVGI 121_ LITTI 126_ ASKGE 131_ LQNWP 136_ DLLPK 141_ LCSLL 146_ DSEDY 151_ NTCEG 156_ AFGAL 161_ QKICE 166_ DSAEI 171_ LDSDV 176_ LDRPL 181_ NIMIP 186_ KFLQF 191_ FKHSS 196_ PKIRS 201_ HAVAC 206_ VNQFI 211_ ISRTQ 216_ ALMLH 221_ IDSFI 226_ ENLFA 231_ LAGDE 236_ EPEVR 241_ KNVCR 246_ ALVML 251_ LEVRM 256_ DRLLP 261_ HMHNI 266_ VEYML 271_ QRTQD 276_ QDENV 281_ ALEAC 286_ EFWLT 291_ LAEQP 296_ ICKDV 301_ LVRHL 306_ PKLIP 311_ VLVNG 316_ MKYSD 321_ IDIIL 326_ LKGDV 331_ EEDET 336_ IPDSE 341_ QDIRP 346_ RFHRS 351_ RTVAQ 356_ QHDED 361_ GIEEE 366_ DDDDD 371_ EIDDD 376_ DTISD 381_ WNLRK 386_ CSAAA 391_ LDVLA 396_ NVYRD 401_ ELLPH 406_ ILPLL 411_ KELLF 416_ HHEWV 421_ VKESG 426_ ILVLG 431_ AIAEG 436_ CMQGM 441_ IPYLP 446_ ELIPH 451_ LIQCL 456_ SDKKA 461_ LVRSI 466_ TCWTL 471_ SRYAH 476_ WVVSQ 481_ PPDTY 486_ LKPLM 491_ TELLK 496_ RILDS 501_ NKRVQ 506_ EAACS 511_ AFATL 516_ EEEAC 521_ TELVP 526_ YLAYI 531_ LDTLV 536_ FAFSK 541_ YQHKN 546_ LLILY 551_ DAIGT 556_ LADSV 561_ GHHLN 566_ KPEYI 571_ QMLMP 576_ PLIQK 581_ WNMLK 586_ DEDKD 591_ LFPLL 596_ ECLSS 601_ VATAL 606_ QSGFL 611_ PYCEP 616_ VYQRC 621_ VNLVQ 626_ KTLAQ 631_ AMLNN 636_ AQPDQ 641_ YEAPD 646_ KDFMI 651_ VALDL 656_ LSGLA 661_ EGLGG 666_ NIEQL 671_ VARSN 676_ ILTLM 681_ YQCMQ 686_ DKMPE 691_ VRQSS 696_ FALLG 701_ DLTKA 706_ CFQHV 711_ KPCIA 716_ DFMPI 721_ LGTNL 726_ NPEFI 731_ SVCNN 736_ ATWAI 741_ GEISI 746_ QMGIE 751_ MQPYI 756_ PMVLH 761_ QLVEI 766_ INRPN 771_ TPKTL 776_ LENTA 781_ ITIGR 786_ LGYVC 791_ PQEVA 796_ PMLQQ 801_ FIRPW 806_ CTSLR 811_ NIRDN 816_ EEKDS 821_ AFRGI 826_ CTMIS 831_ VNPSG 836_ VIQDF 841_ IFFCD 846_ AVASW 851_ INPKD 856_ DLRDM 861_ FCKIL 866_ HGFKN 871_ QVGDE 876_ NWRRF 881_ SDQFP 886_ LPLKE 891_RLAAF
1: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349)
2: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev