Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
1_MSRIE 6_ SLTRA 11_ RIDRS 16_ RELAS 21_ KTREK 26_ EKMKE 31_ AKDAR 36_ YTNGH 41_ LFTTI 46_ SVSGM 51_ TMCYA 56_ CNKSI 61_ TAKEA 66_ LICPT 71_ CNVTI 76_ HNRCK 81_ DTLAN 86_ CTKVK 91_ QKQQK 96_ AALLK 101_ NNTAL 106_ QSVSL 111_ RSKTT 116_ IRERP 121_ SSAIY 126_ PSDSF 131_ RQSLL 136_ GSRRG 141_ RSSLS 146_ LAKSV 151_ STTNI 156_ AGHFN 161_ DESPL 166_ GLRRI 171_ LSQST 176_ DSLNM 181_ RNRTL 186_ SVESL 191_ IDEAE 196_ VIYSE 201_ LMSDF 206_ EMDEK 211_ DFAAD 216_ SWSLA 221_ VDSSF 226_ LQQHK 231_ KEVMK 236_ QQDVI 241_ YELIQ 246_ TELHH 251_ VRTLK 256_ IMTRL 261_ FRTGM 266_ LEELH 271_ LEPGV 276_ VQGLF 281_ PCVDE 286_ LSDIH 291_ TRFLS 296_ QLLER 301_ RRQAL 306_ CPGST 311_ RNFVI 316_ HRLGD 321_ LLISQ 326_ FSGPS 331_ AEQMC 336_ KTYSE 341_ FCSRH 346_ SKALK 351_ LYKEL 356_ YARDK 361_ RFQQF 366_ IRKVT 371_ RPAVL 376_ KRHGV 381_ QECIL 386_ LVTQR 391_ ITKYP 396_ LLISR 401_ ILQHS 406_ HGIEE 411_ ERQDL 416_ TTALG 421_ LVKEL 426_ LSNVD 431_ EGIYQ 436_ LEKGA 441_ RLQEI 446_ YNRMD 451_ PRAQT 456_ PVPGK 461_ GPFGR 466_ EELLR 471_ RKLIH 476_ DGCLL 481_ WKTAT 486_ GRFKD 491_ VLVLL 496_ MTDVL 501_ VFLQE 506_ KDQKY 511_ IFPTL 516_ DKPSV 521_ VSLQN 526_ LIVRD 531_ IANQE 536_ KGMFL 541_ ISAAP 546_ PEMYE 551_ VHTAS 556_ RDDRS 561_ TWIRV 566_ IQQSV 571_ RTCPS 576_ REDFP 581_ LIETE 586_ DEAYL 591_ RRIKM 596_ ELQQK 601_ DRALV 606_ ELLRE 611_ KVGLF 616_ AEMTH 621_ FQAEE 626_ DGGSG 631_ MALPT 636_ LPRGL 641_ FRSES 646_ LESPR 651_ GERLL 656_ QDAIR 661_ EVEGL 666_ KDLLV 671_ GPGVE 676_ LLLTP 681_ REPAL 686_ PLEPD 691_ SGGNT 696_ SPGVT 701_ ANGEA 706_ RTFNG 711_ SIELC 716_ RADSD 721_ SSQRD 726_ RNGNQ 731_ LRSPQ 736_ EEALQ 741_ RLVNL 746_ YGLLH 751_ GLQAA 756_ VAQQD 761_ TLMEA 766_ RFPEG 771_ PERRE 776_ KLCRA 781_ NSRDG 786_ EAGRA 791_ GAAPV 796_ APEKQ 801_ ATELA 806_ LLQRQ 811_ HALLQ 816_ EELRR 821_ CRRLG 826_ EERAT 831_ EAGSL 836_ EARLR 841_ ESEQA 846_ RALLE 851_ REAEE 856_ ARRQL 861_ AALGQ 866_ TEPLP 871_ AEAPW 876_ ARRPV 881_ DPRRR 886_ SLPAG 891_ DALYL 896_ SFNPP 901_ QPSRG 906_ TDRLD 911_ LPVTT 916_ RSVHR 921_ NFEDR 926_ ERQEL 931_ GSPEE 936_ RLQDS 941_ SDPDT 946_ GSEEE 951_ GSSRL 956_ SPPHS 961_ PRDFT 966_ RMQDI 971_ PEETE 976_ SRDGE 981_AVASE
1: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity)