Interferon regulatory factor 7 (IRF-7)
1_MALAP 6_ ERAAP 11_ RVLFG 16_ EWLLG 21_ EISSG 26_ CYEGL 31_ QWLDE 36_ ARTCF 41_ RVPWK 46_ HFARK 51_ DLSEA 56_ DARIF 61_ KAWAV 66_ ARGRW 71_ PPSSR 76_ GGGPP 81_ PEAET 86_ AERAG 91_ WKTNF 96_ RCALR 101_ STRRF 106_ VMLRD 111_ NSGDP 116_ ADPHK 121_ VYALS 126_ RELCW 131_ REGPG 136_ TDQTE 141_ AEAPA 146_ AVPPP 151_ QGGPP 156_ GPFLA 161_ HTHAG 166_ LQAPG 171_ PLPAP 176_ AGDKG 181_ DLLLQ 186_ AVQQS 191_ CLADH 196_ LLTAS 201_ WGADP 206_ VPTKA 211_ PGEGQ 216_ EGLPL 221_ TGACA 226_ GGPGL 231_ PAGEL 236_ YGWAV 241_ ETTPS 246_ PGPQP 251_ AALTT 256_ GEAAA 261_ PESPH 266_ QAEPY 271_ LSPSP 276_ SACTA 281_ VQEPS 286_ PGALD 291_ VTIMY 296_ KGRTV 301_ LQKVV 306_ GHPSC 311_ TFLYG 316_ PPDPA 321_ VRATD 326_ PQQVA 331_ FPSPA 336_ ELPDQ 341_ KQLRY 346_ TEELL 351_ RHVAP 356_ GLHLE 361_ LRGPQ 366_ LWARR 371_ MGKCK 376_ VYWEV 381_ GGPPG 386_ SASPS 391_ TPACL 396_ LPRNC 401_ DTPIF 406_ DFRVF 411_ FQELV 416_ EFRAR 421_ QRRGS 426_ PRYTI 431_ YLGFG 436_ QDLSA 441_ GRPKE 446_ KSLVL 451_ VKLEP 456_ WLCRV 461_ HLEGT 466_ QREGV 471_ SSLDS 476_ SSLSL 481_ CLSSA 486_ NSLYD 491_ DIECF 496_LMELE
1: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045)