Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)
1_MAVEE 6_ LQSII 11_ KRCQI 16_ LEEQD 21_ FKEED 26_ FGLFQ 31_ LAGQR 36_ CIEEG 41_ HTDQL 46_ LEIIQ 51_ NEKNK 56_ VIIKN 61_ MGWNL 66_ VGPVV 71_ RCLLC 76_ KDKED 81_ SKRKV 86_ YFLIF 91_ DLLVK 96_ LCNPK 101_ ELLLG 106_ LLELI 111_ EEPSG 116_ KQISQ 121_ SILLL 126_ LQPLQ 131_ TVIQK 136_ LHNKA 141_ YSIGL 146_ ALSTL 151_ WNQLS 156_ LLPVP 161_ YSKEQ 166_ IQMDD 171_ YGLCQ 176_ CCKAL 181_ IEFTK 186_ PFVEE 191_ VIDNK 196_ ENSLE 201_ NEKLK 206_ DELLK 211_ FCFKS 216_ LKCPL 221_ LTAQF 226_ FEQSE 231_ EGGND 236_ PFRYF 241_ ASEII 246_ GFLSA 251_ IGHPF 256_ PKMIF 261_ NHGRK 266_ KRTWN 271_ YLEFE 276_ EEENK 281_ QLADS 286_ MASLA 291_ YLVFV 296_ QGIHI 301_ DQLPM 306_ VLSPL 311_ YLLQF 316_ NMGHI 321_ EVFLQ 326_ RTEES 331_ VISKG 336_ LELLE 341_ NSLLR 346_ IEDNS 351_ LLYQY 356_ LEIKS 361_ FLTVP 366_ QGLVK 371_ VMTLC 376_ PIETL 381_ RKKSL 386_ AMLQL 391_ YINKL 396_ DSQGK 401_ YTLFR 406_ CLLNT 411_ SNHSG 416_ VEAFI 421_ IQNIK 426_ NQIDM 431_ SLKRT 436_ RNNKW 441_ FTGPQ 446_ LISLL 451_ DLVLF 456_ LPEGA 461_ ETDLL 466_ QNSDR 471_ IMASL 476_ NLLRY 481_ LVIKD 486_ NENDN 491_ QTGLW 496_ TELGN 501_ IENNF 506_ LKPLH 511_ IGLNM 516_ SKAHY 521_ EAEIK 526_ NSQEA 531_ QKSKD 536_ LCSIT 541_ VSGEE 546_ IPNMP 551_ PEMQL 556_ KVLHS 561_ ALFTF 566_ DLIES 571_ VLARV 576_ EELIE 581_ IKTKS 586_TSEEN
1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281)