Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)
1_MQRRG 6_ ALFGM 11_ PGGSG 16_ GRKMA 21_ AGDIG 26_ ELLVP 31_ HMPTI 36_ RVPRS 41_ GDRVY 46_ KNECA 51_ FSYDS 56_ PNSEG 61_ GLYVC 66_ MNTFL 71_ AFGRE 76_ HVERH 81_ FRKTG 86_ QSVYM 91_ HLKRH 96_ VREKV 101_ RGASG 106_ GALPK 111_ RRNSK 116_ IFLDL 121_ DTDDD 126_ LNSDD 131_ YEYED 136_ EAKLV 141_ IFPDH 146_ YEIAL 151_ PNIEE 156_ LPALV 161_ TIACD 166_ AVLSS 171_ KSPYR 176_ KQDPD 181_ TWENE 186_ LPVSK 191_ YANNL 196_ TQLDN 201_ GVRIP 206_ PSGWK 211_ CARCD 216_ LRENL 221_ WLNLT 226_ DGSVL 231_ CGKWF 236_ FDSSG 241_ GNGHA 246_ LEHYR 251_ DMGYP 256_ LAVKL 261_ GTITP 266_ DGADV 271_ YSFQE 276_ EEPVL 281_ DPHLA 286_ KHLAH 291_ FGIDM 296_ LHMHG 301_ TENGL 306_ QDNDI 311_ KLRVS 316_ EWEVI 321_ QESGT 326_ KLKPM 331_ YGPGY 336_ TGLKN 341_ LGNSC 346_ YLSSV 351_ MQAIF 356_ SIPEF 361_ QRAYV 366_ GNLPR 371_ IFDYS 376_ PLDPT 381_ QDFNT 386_ QMTKL 391_ GHGLL 396_ SGQYS 401_ KPPVK 406_ SELIE 411_ QVMKE 416_ EHKPQ 421_ QNGIS 426_ PRMFK 431_ AFVSK 436_ SHPEF 441_ SSNRQ 446_ QDAQE 451_ FFLHL 456_ VNLVE 461_ RNRIG 466_ SENPS 471_ DVFRF 476_ LVEER 481_ IQCCQ 486_ TRKVR 491_ YTERV 496_ DYLMQ 501_ LPVAM 506_ EAATN 511_ KDELI 516_ AYELT 521_ RREAE 526_ ANRRP 531_ LPELV 536_ RAKIP 541_ FSACL 546_ QAFSE 551_ PENVD 556_ DFWSS 561_ ALQAK 566_ SAGVK 571_ TSRFA 576_ SFPEY 581_ LVVQI 586_ KKFTF 591_ GLDWV 596_ PKKFD 601_ VSIDM 606_ PDLLD 611_ INHLR 616_ ARGLQ 621_ PGEEE 626_ LPDIS 631_ PPIVI 636_ PDDSK 641_ DRLMN 646_ QLIDP 651_ SDIDE 656_ SSVMQ 661_ LAEMG 666_ FPLEA 671_ CRKAV 676_ YFTGN 681_ MGAEV 686_ AFNWI 691_ IVHME 696_ EPDFA 701_ EPLTM 706_ PGYGG 711_ AASAG 716_ ASVFG 721_ ASGLD 726_ NQPPE 731_ EIVAI 736_ ITSMG 741_ FQRNQ 746_ AIQAL 751_ RATNN 756_ NLERA 761_ LDWIF 766_ SHPEF 771_ EEDSD 776_ FVIEM 781_ ENNAN 786_ ANIIS 791_ EAKPE 796_ GPRVK 801_ DGSGT 806_ YELFA 811_ FISHM 816_ GTSTM 821_ SGHYI 826_ CHIKK 831_ EGRWV 836_ IYNDH 841_ KVCAS 846_ ERPPK 851_ DLGYM 856_YFYRR
1: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493)