Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
1_MTATT 6_ RGSPV 11_ GGNDN 16_ QGQAP 21_ DGQSQ 26_ PPLQQ 31_ NQTSS 36_ PDSSN 41_ ENSPA 46_ TPPDE 51_ QGQGD 56_ APPQL 61_ EDEEP 66_ AFPHT 71_ DLAKL 76_ DDMIN 81_ RPRWV 86_ VPVLP 91_ KGELE 96_ VLLEA 101_ AIDLS 106_ KKGLD 111_ VKSEA 116_ CQRFF 121_ RDGLT 126_ ISFTK 131_ ILTDE 136_ AVSGW 141_ KFEIH 146_ RCIIN 151_ NTHRL 156_ VELCV 161_ AKLSQ 166_ DWFPL 171_ LELLA 176_ MALNP 181_ HCKFH 186_ IYNGT 191_ RPCES 196_ VSSSV 201_ QLPED 206_ ELFAR 211_ SPDPR 216_ SPKGW 221_ LVDLL 226_ NKFGT 231_ LNGFQ 236_ ILHDR 241_ FINGS 246_ ALNVQ 251_ IIAAL 256_ IKPFG 261_ QCYEF 266_ LTLHT 271_ VKKYF 276_ LPIIE 281_ MVPQF 286_ LENLT 291_ DEELK 296_ KEAKN 301_ EAKND 306_ ALSMI 311_ IKSLK 316_ NLASR 321_ VPGQE 326_ ETVKN 331_ LEIFR 336_ LKMIL 341_ RLLQI 346_ SSFNG 351_ KMNAL 356_ NEVNK 361_ VISSV 366_ SYYTH 371_ RHGNP 376_ EEEEW 381_ LTAER 386_ MAEWI 391_ QQNNI 396_ LSIVL 401_ RDSLH 406_ QPQYV 411_ EKLEK 416_ ILRFV 421_ IKEKA 426_ LTLQD 431_ LDNIW 436_ AAQAG 441_ KHEAI 446_ VKNVH 451_ DLLAK 456_ LAWDF 461_ SPEQL 466_ DHLFD 471_ CFKAS 476_ WTNAS 481_ KKQRE 486_ KLLEL 491_ IRRLA 496_ EDDKD 501_ GVMAH 506_ KVLNL 511_ LWNLA 516_ HSDDV 521_ PVDIM 526_ DLALS 531_ AHIKI 536_ LDYSC 541_ SQDRD 546_ TQKIQ 551_ WIDRF 556_ IEELR 561_ TNDKW 566_ VIPAL 571_ KQIRE 576_ ICSLF 581_ GEAPQ 586_ NLSQT 591_ QRSPH 596_ VFYRH 601_ DLINQ 606_ LQHNH 611_ ALVTL 616_ VAENL 621_ ATYME 626_ SMRLY 631_ ARDHE 636_ DYDPQ 641_ TVRLG 646_ SRYSH 651_ VQEVQ 656_ ERLNF 661_ LRFLL 666_ KDGQL 671_ WLCAP 676_ QAKQI 681_ WKCLA 686_ ENAVY 691_ LCDRE 696_ ACFKW 701_ YSKLM 706_ GDEPD 711_ LDPDI 716_ NKDFF 721_ ESNVL 726_ QLDPS 731_ LLTEN 736_ GMKCF 741_ ERFFK 746_ AVNCR 751_ EGKLV 756_ AKRRA 761_ YMMDD 766_ LELIG 771_ LDYLW 776_ RVVIQ 781_ SNDDI 786_ ASRAI 791_ DLLKE 796_ IYTNL 801_ GPRLQ 806_ VNQVV 811_ IHEDF 816_ IQSCF 821_ DRLKA 826_ SYDTL 831_ CVLDG 836_ DKDSV 841_ NCARQ 846_ EAVRM 851_ VRVLT 856_ VLREY 861_ INECD 866_ SDYHE 871_ ERTIL 876_ PMSRA 881_ FRGKH 886_ LSFVV 891_ RFPNQ 896_ GRQVD 901_ DLEVW 906_ SHTND 911_ TIGSV 916_ RRCIL 921_ NRIKA 926_ NVAHT 931_ KIELF 936_ VGGEL 941_ IDPAD 946_ DRKLI 951_ GQLNL 956_ KDKSL 961_ ITAKL 966_ TQISS 971_ NMPSS 976_ PDSSS 981_ DSSTG 986_ SPGNH 991_ GNHYS 996_ DGPNP 1001_ EVESC 1006_ LPGVI 1011_ MSLHP 1016_ RYISF 1021_ LWQVA 1026_ DLGSS 1031_ LNMPP 1036_ LRDGA 1041_ RVLMK 1046_ LMPPD 1051_ STTIE 1056_ KLRAI 1061_ CLDHA 1066_ KLGES 1071_ SLSPS 1076_ LDSLF 1081_ FGPSA 1086_ SQVLY 1091_ LTEVV 1096_ YALLM 1101_ PAGAP 1106_ LADDS 1111_ SDFQF 1116_ HFLKS 1121_ GGLPL 1126_ VLSML 1131_ TRNNF 1136_ LPNAD 1141_ METRR 1146_ GAYLN 1151_ ALKIA 1156_ KLLLT 1161_ AIGYG 1166_ HVRAV 1171_ AEACQ 1176_ PGVEG 1181_ VNPMT 1186_ QINQV 1191_ THDQA 1196_ VVLQS 1201_ ALQSI 1206_ PNPSS 1211_ ECMLR 1216_ NVSVR 1221_ LAQQI 1226_ SDEAS 1231_ RYMPD 1236_ ICVIR 1241_ AIQKI 1246_ IWASG 1251_ CGSLQ 1256_ LVFSP 1261_ NEEIT 1266_ KIYEK 1271_ TNAGN 1276_ EPDLE 1281_ DEQVC 1286_ CEALE 1291_ VMTLC 1296_ FALIP 1301_ TALDA 1306_ LSKEK 1311_ AWQTF 1316_ IIDLL 1321_ LHCHS 1326_ KTVRQ 1331_ VAQEQ 1336_ FFLMC 1341_ TRCCM 1346_ GHRPL 1351_ LFFIT 1356_ LLFTV 1361_ LGSTA 1366_ RERAK 1371_ HSGDY 1376_ FTLLR 1381_ HLLNY 1386_ AYNSN 1391_ INVPN 1396_ AEVLL 1401_ NNEID 1406_ WLKRI 1411_ RDDVK 1416_ RTGET 1421_ GIEET 1426_ ILEGH 1431_ LGVTK 1436_ ELLAF 1441_ QTSEK 1446_ KFHIG 1451_ CEKGG 1456_ ANLIK 1461_ ELIDD 1466_ FIFPA 1471_ SNVYL 1476_ QYMRN 1481_ GELPA 1486_ EQAIP 1491_ VCGSP 1496_ PTINA 1501_ GFELL 1506_ VALAV 1511_ GCVRN 1516_ LKQIV 1521_ DSLTE 1526_ MYYIG 1531_ TAITT 1536_ CEALT 1541_ EWEYL 1546_ PPVGP 1551_ RPPKG 1556_ FVGLK 1561_ NAGAT 1566_ CYMNS 1571_ VIQQL 1576_ YMIPS 1581_ IRNGI 1586_ LAIEG 1591_ TGSDV 1596_ DDDMS 1601_ GDEKQ 1606_ DNESN 1611_ VDPRD 1616_ DVFGY 1621_ PQQFE 1626_ DKPAL 1631_ SKTED 1636_ RKEYN 1641_ IGVLR 1646_ HLQVI 1651_ FGHLA 1656_ ASRLQ 1661_ YYVPR 1666_ GFWKQ 1671_ FRLWG 1676_ EPVNL 1681_ REQHD 1686_ ALEFF 1691_ NSLVD 1696_ SLDEA 1701_ LKALG 1706_ HPAML 1711_ SKVLG 1716_ GSFAD 1721_ QKICQ 1726_ GCPHR 1731_ YECEE 1736_ SFTTL 1741_ NVDIR 1746_ NHQNL 1751_ LDSLE 1756_ QYVKG 1761_ DLLEG 1766_ ANAYH 1771_ CEKCN 1776_ KKVDT 1781_ VKRLL 1786_ IKKLP 1791_ PVLAI 1796_ QLKRF 1801_ DYDWE 1806_ RECAI 1811_ KFNDY 1816_ FEFPR 1821_ ELDME 1826_ PYTVA 1831_ GVAKL 1836_ EGDNV 1841_ NPESQ 1846_ LIQQS 1851_ EQSES 1856_ ETAGS 1861_ TKYRL 1866_ VGVLV 1871_ HSGQA 1876_ SGGHY 1881_ YSYII 1886_ QRNGG 1891_ DGERN 1896_ RWYKF 1901_ DDGDV 1906_ TECKM 1911_ DDDEE 1916_ MKNQC 1921_ FGGEY 1926_ MGEVF 1931_ DHMMK 1936_ RMSYR 1941_ RQKRW 1946_ WNAYI 1951_ LFYER 1956_ MDTID 1961_ QDDEL 1966_ IRYIS 1971_ ELAIT 1976_ TRPHQ 1981_ IIMPS 1986_ AIERS 1991_ VRKQN 1996_ VQFMH 2001_ NRMQY 2006_ SMEYF 2011_ QFMKK 2016_ LLTCN 2021_ GVYLN 2026_ PPPGQ 2031_ DHLLP 2036_ EAEEI 2041_ TMISI 2046_ QLAAR 2051_ FLFTT 2056_ GFHTK 2061_ KVVRG 2066_ SASDW 2071_ YDALC 2076_ ILLRH 2081_ SKNVR 2086_ FWFAH 2091_ NVLFN 2096_ VSNRF 2101_ SEYLL 2106_ ECPSA 2111_ EVRGA 2116_ FAKLI 2121_ VFIAH 2126_ FSLQD 2131_ GPCPS 2136_ PFASP 2141_ GPSSQ 2146_ AYDNL 2151_ SLSDH 2156_ LLRAV 2161_ LNLLR 2166_ REVSE 2171_ HGRHL 2176_ QQYFN 2181_ LFVMY 2186_ ANLGV 2191_ AEKTQ 2196_ LLKLS 2201_ VPATF 2206_ MLVSL 2211_ DEGPG 2216_ PPIKY 2221_ QYAEL 2226_ GKLYS 2231_ VVSQL 2236_ IRCCN 2241_ VSSRM 2246_ QSSIN 2251_ GNPPL 2256_ PNPFG 2261_ DPNLS 2266_ QPIMP 2271_ IQQNV 2276_ ADILF 2281_ VRTSY 2286_ VKKII 2291_ EDCSN 2296_ SEETV 2301_ KLLRF 2306_ CCWEN 2311_ PQFSS 2316_ TVLSE 2321_ LLWQV 2326_ AYSYT 2331_ YELRP 2336_ YLDLL 2341_ LQILL 2346_ IEDSW 2351_ QTHRI 2356_ HNALK 2361_ GIPDD 2366_ RDGLF 2371_ DTIQR 2376_ SKNHY 2381_ QKRAY 2386_ QCIKC 2391_ MVALF 2396_ SNCPV 2401_ AYQIL 2406_ QGNGD 2411_ LKRKW 2416_ TWAVE 2421_ WLGDE 2426_ LERRP 2431_ YTGNP 2436_ QYTYN 2441_ NWSPP 2446_ VQSNE 2451_ TSNGY 2456_ FLERS 2461_ HSARM 2466_ TLAKA 2471_ CELCP 2476_ EEEPD 2481_ DQDAP 2486_ DEHES 2491_ PPPED 2496_ APLYP 2501_ HSPGS 2506_ QYQQN 2511_ NHVHG 2516_ QPYTG 2521_ PAAHH 2526_ MNNPQ 2531_ RTGQR 2536_ AQENY 2541_ EGSEE 2546_VSPPQ
1: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). Specifically hydrolyzes 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains (PubMed:30914461). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates RNA demethylase enzyme ALKBH5, promoting its stability (PubMed:37454738). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity). Inhibits the activation of the Hippo signaling pathway via deubiquitination of AMOTL2 at 'Lys-347' and 'Lys-408' which prohibits its interaction with and activation of LATS2. Loss of LATS2 activation and subsequent loss of YAP1 phosphorylation results in an increase in YAP1-driven transcription of target genes (PubMed:26598551, PubMed:34404733)