N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2)
1_MELIL 6_ STSPA 11_ ELTLD 16_ PACQP 21_ KLPLD 26_ STCQP 31_ EMTFN 36_ PGPTE 41_ LTLDP 46_ EHQPE 51_ ETPAP 56_ SLAEL 61_ TLEPV 66_ HRRPE 71_ LLDAC 76_ ADLIN 81_ DQWPR 86_ SRTSR 91_ LHSLG 96_ QSSDA 101_ FPLCL 106_ MLLSP 111_ HPTLE 116_ AAPVV 121_ VGHAR 126_ LSRVL 131_ NQPQS 136_ LLVET 141_ VVVAR 146_ ALRGR 151_ GFGRR 156_ LMEGL 161_ EVFAR 166_ ARGFR 171_ KLHLT 176_ THDQV 181_ HFYTH 186_ LGYQL 191_ GEPVQ 196_ GLVFT 201_ SRRLP 206_ ATLLN 211_ AFPTA 216_ PSPRP 221_ PRKAP 226_ NLTAQ 231_ AAPRG 236_ PKGPP 241_ LPPPP 246_ PLPEC 251_ LTISP 256_ PVPSG 261_ PPSKS 266_ LLETQ 271_ YQNVR 276_ GRPIF 281_WMEKD
1: N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992)