Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101)
1_MAGIS 6_ YVASF 11_ FLLLT 16_ KLSIG 21_ QREVT 26_ VQKGP 31_ LFRAE 36_ GYPVS 41_ IGCNV 46_ TGHQG 51_ PSEQH 56_ FQWSV 61_ YLPTN 66_ PTQEV 71_ QIIST 76_ KDAAF 81_ SYAVY 86_ TQRVR 91_ SGDVY 96_ VERVQ 101_ GNSVL 106_ LHISK 111_ LQMKD 116_ AGEYE 121_ CHTPN 126_ TDEKY 131_ YGSYS 136_ AKTNL 141_ IVIPD 146_ TLSAT 151_ MSSQT 156_ LGKEE 161_ GEPLA 166_ LTCEA 171_ SKATA 176_ QHTHL 181_ SVTWY 186_ LTQDG 191_ GGSQA 196_ TEIIS 201_ LSKDF 206_ ILVPG 211_ PLYTE 216_ RFAAS 221_ DVQLN 226_ KLGPT 231_ TFRLS 236_ IERLQ 241_ SSDQG 246_ QLFCE 251_ ATEWI 256_ QDPDE 261_ TWMFI 266_ TKKQT 271_ DQTTL 276_ RIQPA 281_ VKDFQ 286_ VNITA 291_ DSLFA 296_ EGKPL 301_ ELVCL 306_ VVSSG 311_ RDPQL 316_ QGIWF 321_ FNGTE 326_ IAHID 331_ AGGVL 336_ GLKND 341_ YKERA 346_ SQGEL 351_ QVSKL 356_ GPKAF 361_ SLKIF 366_ SLGPE 371_ DEGAY 376_ RCVVA 381_ EVMKT 386_ RTGSW 391_ QVLQR 396_ KQSPD 401_ SHVHL 406_ RKPAA 411_ RSVVM 416_ STKNK 421_ QQVVW 426_ EGETL 431_ AFLCK 436_ AGGAE 441_ SPLSV 446_ SWWHI 451_ PRDQT 456_ QPEFV 461_ AGMGQ 466_ DGIVQ 471_ LGASY 476_ GVPSY 481_ HGNTR 486_ LEKMD 491_ WATFQ 496_ LEITF 501_ TAITD 506_ SGTYE 511_ CRVSE 516_ KSRNQ 521_ ARDLS 526_ WTQKI 531_ SVTVK 536_ SLESS 541_ LQVSL 546_ MSRQP 551_ QVMLT 556_ NTFDL 561_ SCVVR 566_ AGYSD 571_ LKVPL 576_ TVTWQ 581_ FQPAS 586_ SHIFH 591_ QLIRI 596_ THNGT 601_ IEWGN 606_ FLSRF 611_ QKKTK 616_ VSQSL 621_ FRSQL 626_ LVHDA 631_ TEEET 636_ GVYQC 641_ EVEVY 646_ DRNSL 651_ YNNRP 656_ PRASA 661_ ISHPL 666_ RIAVT 671_ LPESK 676_ LKVNS 681_ RSQVQ 686_ ELSIN 691_ SNTDI 696_ ECSIL 701_ SRSNG 706_ NLQLA 711_ IIWYF 716_ SPVST 721_ NASWL 726_ KILEM 731_ DQTNV 736_ IKTGD 741_ EFHTP 746_ QRKQK 751_ FHTEK 756_ VSQDL 761_ FQLHI 766_ LNVED 771_ SDRGK 776_ YHCAV 781_ EEWLL 786_ STNGT 791_ WHKLG 796_ EKKSG 801_ LTELK 806_ LKPTG 811_ SKVRV 816_ SKVYW 821_ TENVT 826_ EHREV 831_ AIRCS 836_ LESVG 841_ SSATL 846_ YSVMW 851_ YWNRE 856_ NSGSK 861_ LLVHL 866_ QHDGL 871_ LEYGE 876_ EGLRR 881_ HLHCY 886_ RSSST 891_ DFVLK 896_ LHQVE 901_ MEDAG 906_ MYWCR 911_ VAEWQ 916_ LHGHP 921_ SKWIN 926_ QASDE 931_ SQRMV 936_ LTVLP 941_ SEPTL 946_ PSRIC 951_ SSAPL 956_ LYFLF 961_ ICPFV 966_ LLLLL 971_ LISLL 976_ CLYWK 981_ ARKLS 986_ TLRSN 991_ TRKEK 996_ ALWVD 1001_ LKEAG 1006_ GVTTN 1011_ RREDE 1016_EEDEG
1: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells