Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
1_MATSN 6_ LLKNK 11_ GSLQF 16_ EDKWD 21_ FMRPI 26_ VLKLL 31_ RQESV 36_ TKQQW 41_ FDLFS 46_ DVHAV 51_ CLWDD 56_ KGPAK 61_ IHQAL 66_ KEDIL 71_ EFIKQ 76_ AQARV 81_ LSHQD 86_ DTALL 91_ KAYIV 96_ EWRKF 101_ FTQCD 106_ ILPKP 111_ FCQLE 116_ ITLMG 121_ KQGSN 126_ KKSNV 131_ EDSIV 136_ RKLML 141_ DTWNE 146_ SIFSN 151_ IKNRL 156_ QDSAM 161_ KLVHA 166_ ERLGE 171_ AFDSQ 176_ LVIGV 181_ RESYV 186_ NLCSN 191_ PEDKL 196_ QIYRD 201_ NFEKA 206_ YLDST 211_ ERFYR 216_ TQAPS 221_ YLQQN 226_ GVQNY 231_ MKYAD 236_ AKLKE 241_ EEKRA 246_ LRYLE 251_ TRREC 256_ NSVEA 261_ LMECC 266_ VNALV 271_ TSFKE 276_ TILAE 281_ CQGMI 286_ KRNET 291_ EKLHL 296_ MFSLM 301_ DKVPN 306_ GIEPM 311_ LKDLE 316_ EHIIS 321_ AGLAD 326_ MVAAA 331_ ETITT 336_ DSEKY 341_ VEQLL 346_ TLFNR 351_ FSKLV 356_ KEAFQ 361_ DDPRF 366_ LTARD 371_ KAYKA 376_ VVNDA 381_ TIFKL 386_ ELPLK 391_ QKGVG 396_ LKTQP 401_ ESKCP 406_ ELLAN 411_ YCDML 416_ LRKTP 421_ LSKKL 426_ TSEEI 431_ EAKLK 436_ EVLLV 441_ LKYVQ 446_ NKDVF 451_ MRYHK 456_ AHLTR 461_ RLILD 466_ ISADS 471_ EIEEN 476_ MVEWL 481_ REVGM 486_ PADYV 491_ NKLAR 496_ MFQDI 501_ KVSED 506_ LNQAF 511_ KEMHK 516_ NNKLA 521_ LPADS 526_ VNIKI 531_ LNAGA 536_ WSRSS 541_ EKVFV 546_ SLPTE 551_ LEDLI 556_ PEVEE 561_ FYKKN 566_ HSGRK 571_ LHWHH 576_ LMSNG 581_ IITFK 586_ NEVGQ 591_ YDLEV 596_ TTFQL 601_ AVLFA 606_ WNQRP 611_ REKIS 616_ FENLK 621_ LATEL 626_ PDAEL 631_ RRTLW 636_ SLVAF 641_ PKLKR 646_ QVLLY 651_ EPQVN 656_ SPKDF 661_ TEGTL 666_ FSVNQ 671_ EFSLI 676_ KNAKV 681_ QKRGK 686_ INLIG 691_ RLQLT 696_ TERMR 701_ EEENE 706_ GIVQL 711_ RILRT 716_ QEAII 721_ QIMKM 726_ RKKIS 731_ NAQLQ 736_ TELVE 741_ ILKNM 746_ FLPQK 751_ KMIKE 756_ QIEWL 761_ IEHKY 766_ IRRDE 771_SDINT
1: Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:15601820, PubMed:21199876, PubMed:21980433, PubMed:23897481, PubMed:25505247, PubMed:27910872, PubMed:32200094, PubMed:33268465, PubMed:35512830, PubMed:38418882). Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:11384984, PubMed:15601820, PubMed:33268465). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable SOCS box-containing substrate recognition component (PubMed:11384984, PubMed:15601820, PubMed:33268465). Acts as a key regulator of neuron positioning during cortex development: component of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). ECS(SOCS1) seems to direct ubiquitination of JAK2 (PubMed:11384984). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (PubMed:33268465). As part of some ECS complex, promotes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). As part of a multisubunit ECS complex, polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of the ECS(RAB40A) complex, mediates RHOU 'Lys-48'-linked ubiquitination and degradation, thus inhibiting focal adhesion disassembly during cell migration (PubMed:26598620). As part of the ECS(RAB40B) complex, mediates LIMA1/EPLIN and RAP2 ubiquitination, thereby regulating actin cytoskeleton dynamics and stress fiber formation during cell migration (PubMed:33999101, PubMed:35293963). May form a cell surface vasopressin receptor (PubMed:9037604)
2: (Microbial infection) Following infection by HIV-1 virus, CUL5 associates with HIV-1 Vif proteins and forms a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) that catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:16636053, PubMed:22190037). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699)
3: (Microbial infection) Seems to be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein