V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)
1_MGELF 6_ RSEEM 11_ TLAQL 16_ FLQSE 21_ AAYCC 26_ VSELG 31_ ELGKV 36_ QFRDL 41_ NPDVN 46_ VFQRK 51_ FVNEV 56_ RRCEE 61_ MDRKL 66_ RFVEK 71_ EIRKA 76_ NIPIM 81_ DTGEN 86_ PEVPF 91_ PRDMI 96_ DLEAN 101_ FEKIE 106_ NELKE 111_ INTNQ 116_ EALKR 121_ NFLEL 126_ TELKF 131_ ILRKT 136_ QQFFD 141_ EMADP 146_ DLLEE 151_ SSSLL 156_ EPSEM 161_ GRGTP 166_ LRLGF 171_ VAGVI 176_ NRERI 181_ PTFER 186_ MLWRV 191_ CRGNV 196_ FLRQA 201_ EIENP 206_ LEDPV 211_ TGDYV 216_ HKSVF 221_ IIFFQ 226_ GDQLK 231_ NRVKK 236_ ICEGF 241_ RASLY 246_ PCPET 251_ PQERK 256_ EMASG 261_ VNTRI 266_ DDLQM 271_ VLNQT 276_ EDHRQ 281_ RVLQA 286_ AAKNI 291_ RVWFI 296_ KVRKM 301_ KAIYH 306_ TLNLC 311_ NIDVT 316_ QKCLI 321_ AEVWC 326_ PVTDL 331_ DSIQF 336_ ALRRG 341_ TEHSG 346_ STVPS 351_ ILNRM 356_ QTNQT 361_ PPTYN 366_ KTNKF 371_ TYGFQ 376_ NIVDA 381_ YGIGT 386_ YREIN 391_ PAPYT 396_ IITFP 401_ FLFAV 406_ MFGDF 411_ GHGIL 416_ MTLFA 421_ VWMVL 426_ RESRI 431_ LSQKN 436_ ENEMF 441_ STVFS 446_ GRYII 451_ LLMGV 456_ FSMYT 461_ GLIYN 466_ DCFSK 471_ SLNIF 476_ GSSWS 481_ VRPMF 486_ TYNWT 491_ EETLR 496_ GNPVL 501_ QLNPA 506_ LPGVF 511_ GGPYP 516_ FGIDP 521_ IWNIA 526_ TNKLT 531_ FLNSF 536_ KMKMS 541_ VILGI 546_ IHMLF 551_ GVSLS 556_ LFNHI 561_ YFKKP 566_ LNIYF 571_ GFIPE 576_ IIFMT 581_ SLFGY 586_ LVILI 591_ FYKWT 596_ AYDAH 601_ TSENA 606_ PSLLI 611_ HFINM 616_ FLFSY 621_ PESGY 626_ SMLYS 631_ GQKGI 636_ QCFLV 641_ VVALL 646_ CVPWM 651_ LLFKP 656_ LVLRR 661_ QYLRR 666_ KHLGT 671_ LNFGG 676_ IRVGN 681_ GPTEE 686_ DAEII 691_ QHDQL 696_ STHSE 701_ DADEP 706_ SEDEV 711_ FDFGD 716_ TMVHQ 721_ AIHTI 726_ EYCLG 731_ CISNT 736_ ASYLR 741_ LWALS 746_ LAHAQ 751_ LSEVL 756_ WTMVI 761_ HIGLS 766_ VKSLA 771_ GGLVL 776_ FFFFT 781_ AFATL 786_ TVAIL 791_ LIMEG 796_ LSAFL 801_ HALRL 806_ HWVEF 811_ QNKFY 816_ SGTGF 821_ KFLPF 826_ SFEHI 831_REGKF
1: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:33065002, PubMed:33833240, PubMed:34909687). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240)