Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)
1_MCASV 6_ KYNIR 11_ GPALI 16_ PRMKT 21_ KHRIY 26_ YITLF 31_ SIVLL 36_ GLIAT 41_ GMFQF 46_ WPHSI 51_ ESSND 56_ WNVEK 61_ RSIRD 66_ VPVVR 71_ LPADS 76_ PIPER 81_ GDLSC 86_ RMHTC 91_ FDVYR 96_ CGFNP 101_ KNKIK 106_ VYIYA 111_ LKKYV 116_ DDFGV 121_ SVSNT 126_ ISREY 131_ NELLM 136_ AISDS 141_ DYYTD 146_ DINRA 151_ CLFVP 156_ SIDVL 161_ NQNTL 166_ RIKET 171_ AQAMA 176_ QLSRW 181_ DRGTN 186_ HLLFN 191_ MLPGG 196_ PPDYN 201_ TALDV 206_ PRDRA 211_ LLAGG 216_ GFSTW 221_ TYRQG 226_ YDVSI 231_ PVYSP 236_ LSAEV 241_ DLPEK 246_ GPGPR 251_ QYFLL 256_ SSQVG 261_ LHPEY 266_ REDLE 271_ ALQVK 276_ HGESV 281_ LVLDK 286_ CTNLS 291_ EGVLS 296_ VRKRC 301_ HKHQV 306_ FDYPQ 311_ VLQEA 316_ TFCVV 321_ LRGAR 326_ LGQAV 331_ LSDVL 336_ QAGCV 341_ PVVIA 346_ DSYIL 351_ PFSEV 356_ LDWKR 361_ ASVVV 366_ PEEKM 371_ SDVYS 376_ ILQSI 381_ PQRQI 386_ EEMQR 391_ QARWF 396_ WEAYF 401_ QSIKA 406_ IALAT 411_ LQIIN 416_ DRIYP 421_ YAAIS 426_ YEEWN 431_ DPPAV 436_ KWGSV 441_ SNPLF 446_ LPLIP 451_ PQSQG 456_ FTAIV 461_ LTYDR 466_ VESLF 471_ RVITE 476_ VSKVP 481_ SLSKL 486_ LVVWN 491_ NQNKN 496_ PPEDS 501_ LWPKI 506_ RVPLK 511_ VVRTA 516_ ENKLS 521_ NRFFP 526_ YDEIE 531_ TEAVL 536_ AIDDD 541_ IIMLT 546_ SDELQ 551_ FGYEV 556_ WREFP 561_ DRLVG 566_ YPGRL 571_ HLWDH 576_ EMNKW 581_ KYESE 586_ WTNEV 591_ SMVLT 596_ GAAFY 601_ HKYFN 606_ YLYTY 611_ KMPGD 616_ IKNWV 621_ DAHMN 626_ CEDIA 631_ MNFLV 636_ ANVTG 641_ KAVIK 646_ VTPRK 651_ KFKCP 656_ ECTAI 661_ DGLSL 666_ DQTHM 671_ VERSE 676_ CINKF 681_ ASVFG 686_ TMPLK 691_ VVEHR 696_ ADPVL 701_ YKDDF 706_ PEKLK 711_SFPNI
1: Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone (PubMed:22660413, PubMed:36402845, PubMed:36593275). Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (PubMed:36402845, PubMed:36593275). Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling (PubMed:19344451, PubMed:22660413)