Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
1_MAAFG 6_ ILSYE 11_ HRPLK 16_ RPRLG 21_ PPDVY 26_ PQDPK 31_ QKEDE 36_ LTALN 41_ VKQGF 46_ NNQPA 51_ VSGDE 56_ HGSAK 61_ NVSFN 66_ PAKIS 71_ SNFSS 76_ IIAEK 81_ LRCNT 86_ LPDTG 91_ RRKPQ 96_ VNQKD 101_ NFWLV 106_ TARSQ 111_ SAINT 116_ WFTDL 121_ AGTKP 126_ LTQLA 131_ KKVPI 136_ FSKKE 141_ EVFGY 146_ LAKYT 151_ VPVMR 156_ AAWLI 161_ KMTCA 166_ YYAAI 171_ SETKV 176_ KKRHV 181_ DPFME 186_ WTQII 191_ TKYLW 196_ EQLQK 201_ MAEYY 206_ RPGPA 211_ GSGGC 216_ GSTIG 221_ PLPHD 226_ VEVAI 231_ RQWDY 236_ TEKLA 241_ MFMFQ 246_ DGMLD 251_ RHEFL 256_ TWVLE 261_ CFEKI 266_ RPGED 271_ ELLKL 276_ LLPLL 281_ LRYSG 286_ EFVQS 291_ AYLSR 296_ RLAYF 301_ CTRRL 306_ ALQLD 311_ GVSSH 316_ SSHVI 321_ SAQST 326_ STLPT 331_ TPAPQ 336_ PPTSS 341_ TPSTP 346_ FSDLL 351_ MCPQH 356_ RPLVF 361_ GLSCI 366_ LQTIL 371_ LCCPS 376_ ALVWH 381_ YSLTD 386_ SRIKT 391_ GSPLD 396_ HLPIA 401_ PSNLP 406_ MPEGN 411_ SAFTQ 416_ QVRAK 421_ LREIE 426_ QQIKE 431_ RGQAV 436_ EVRWS 441_ FDKCQ 446_ EATAG 451_ FTIGR 456_ VLHTL 461_ EVLDS 466_ HSFER 471_ SDFSN 476_ SLDSL 481_ CNRIF 486_ GLGPS 491_ KDGHE 496_ ISSDD 501_ DAVVS 506_ LLCEW 511_ AVSCK 516_ RSGRH 521_ RAMVV 526_ AKLLE 531_ KRQAE 536_ IEAER 541_ CGESE 546_ AADEK 551_ GSIAS 556_ GSLSA 561_ PSAPI 566_ FQDVL 571_ LQFLD 576_ TQAPM 581_ LTDPR 586_ SESER 591_ VEFFN 596_ LVLLF 601_ CELIR 606_ HDVFS 611_ HNMYT 616_ CTLIS 621_ RGDLA 626_ FGAPG 631_ PRPPS 636_ PFDDP 641_ ADDPE 646_ HKEAE 651_ GSSSS 656_ KLEDP 661_ GLSES 666_ MDIDP 671_ SSSVL 676_ FEDME 681_ KPDFS 686_ LFSPT 691_ MPCEG 696_ KGSPS 701_ PEKPD 706_ VEKEV 711_ KPPPK 716_ EKIEG 721_ TLGVL 726_ YDQPR 731_ HVQYA 736_ THFPI 741_ PQEES 746_ CSHEC 751_ NQRLV 756_ VLFGV 761_ GKQRD 766_ DARHA 771_ IKKIT 776_ KDILK 781_ VLNRK 786_ GTAET 791_ DQLAP 796_ IVPLN 801_ PGDLT 806_ FLGGE 811_ DGQKR 816_ RRNRP 821_ EAFPT 826_ AEDIF 831_ AKFQH 836_ LSHYD 841_ QHQVT 846_ AQVSR 851_ NVLEQ 856_ ITSFA 861_ LGMSY 866_ HLPLV 871_ QHVQF 876_ IFDLM 881_ EYSLS 886_ ISGLI 891_ DFAIQ 896_ LLNEL 901_ SVVEA 906_ ELLLK 911_ SSDLV 916_ GSYTT 921_ SLCLC 926_ IVAVL 931_ RHYHA 936_ CLILN 941_ QDQMA 946_ QVFEG 951_ LCGVV 956_ KHGMN 961_ RSDGS 966_ SAERC 971_ ILAYL 976_ YDLYT 981_ SCSHL 986_ KNKFG 991_ ELFSD 996_ FCSKV 1001_ KNTIY 1006_ CNVEP 1011_ SESNM 1016_ RWAPE 1021_ FMIDT 1026_ LENPA 1031_ AHTFT 1036_ YTGLG 1041_ KSLSE 1046_ NPANR 1051_ YSFVC 1056_ NALMH 1061_ VCVGH 1066_ HDPDR 1071_ VNDIA 1076_ ILCAE 1081_ LTGYC 1086_ KSLSA 1091_ EWLGV 1096_ LKALC 1101_ CSSNN 1106_ GTCGF 1111_ NDLLC 1116_ NVDVS 1121_ DLSFH 1126_ DSLAT 1131_ FVAIL 1136_ IARQC 1141_ LLLED 1146_ LIRCA 1151_ AIPSL 1156_ LNAAC 1161_ SEQDS 1166_ EPGAR 1171_ LTCRI 1176_ LLHLF 1181_ KTPQL 1186_ NPCQS 1191_ DGNKP 1196_ TVGIR 1201_ SSCDR 1206_ HLLAA 1211_ SQNRI 1216_ VDGAV 1221_ FAVLK 1226_ AVFVL 1231_ GDAEL 1236_ KGSGF 1241_ TVTGG 1246_ TEELP 1251_ EEEGG 1256_ GGSGG 1261_ RRQGG 1266_ RNISV 1271_ ETASL 1276_ DVYAK 1281_ YVLRS 1286_ ICQQE 1291_ WVGER 1296_ CLKSL 1301_ CEDSN 1306_ DLQDP 1311_ VLSSA 1316_ QAQRL 1321_ MQLIC 1326_ YPHRL 1331_ LDNED 1336_ GENPQ 1341_ RQRIK 1346_ RILQN 1351_ LDQWT 1356_ MRQSS 1361_ LELQL 1366_ MIKQT 1371_ PNNEM 1376_ NSLLE 1381_ NIAKA 1386_ TIEVF 1391_ QQSAE 1396_ TGSSS 1401_ GSTAS 1406_ NMPSS 1411_ SKTKP 1416_ VLSSL 1421_ ERSGV 1426_ WLVAP 1431_ LIAKL 1436_ PTSVQ 1441_ GHVLK 1446_ AAGEE 1451_ LEKGQ 1456_ HLGSS 1461_ SRKER 1466_ DRQKQ 1471_ KSMSL 1476_ LSQQP 1481_ FLSLV 1486_ LTCLK 1491_ GQDEQ 1496_ REGLL 1501_ TSLYS 1506_ QVHQI 1511_ VNNWR 1516_ DDQYL 1521_ DDCKP 1526_ KQLMH 1531_ EALKL 1536_ RLNLV 1541_ GGMFD 1546_ TVQRS 1551_ TQQTT 1556_ EWAML 1561_ LLEII 1566_ ISGTV 1571_ DMQSN 1576_ NELFT 1581_ TVLDM 1586_ LSVLI 1591_ NGTLA 1596_ ADMSS 1601_ ISQGS 1606_ MEENK 1611_ RAYMN 1616_ LAKKL 1621_ QKELG 1626_ ERQSD 1631_ SLEKV 1636_ RQLLP 1641_ LPKQT 1646_ RDVIT 1651_ CEPQG 1656_ SLIDT 1661_ KGNKI 1666_ AGFDS 1671_ IFKKE 1676_ GLQVS 1681_ TKQKI 1686_ SPWDL 1691_ FEGLK 1696_ PSAPL 1701_ SWGWF 1706_ GTVRV 1711_ DRRVA 1716_ RGEEQ 1721_ QRLLL 1726_ YHTHL 1731_ RPRPR 1736_ AYYLE 1741_ PLPLP 1746_ PEDEE 1751_ PPAPT 1756_ LLEPE 1761_ KKAPE 1766_ PPKTD 1771_ KPGAA 1776_ PPSTE 1781_ ERKKK 1786_ STKGK 1791_ KRSQP 1796_ ATKTE 1801_ DYGMG 1806_ PGRSG 1811_ PYGVT 1816_ VPPDL 1821_ LHHPN 1826_ PGSIT 1831_ HLNYR 1836_ QGSIG 1841_ LYTQN 1846_ QPLPA 1851_ GGPRV 1856_ DPYRP 1861_ VRLPM 1866_ QKLPT 1871_ RPTYP 1876_ GVLPT 1881_ TMTGV 1886_ MGLEP 1891_ SSYKT 1896_ SVYRQ 1901_ QQPAV 1906_ PQGQR 1911_ LRQQL 1916_ QQSQG 1921_ MLGQS 1926_ SVHQM 1931_ TPSSS 1936_ YGLQT 1941_ SQGYT 1946_ PYVSH 1951_ VGLQQ 1956_ HTGPA 1961_ GTMVP 1966_ PSYSS 1971_ QPYQS 1976_ THPST 1981_ NPTLV 1986_ DPTRH 1991_ LQQRP 1996_ SGYVH 2001_ QQAPT 2006_ YGHGL 2011_ TSTQR 2016_ FSHQT 2021_ LQQTP 2026_ MISTM 2031_ TPMSA 2036_ QGVQA 2041_ GVRST 2046_ AILPE 2051_ QQQQQ 2056_ QQQQQ 2061_ QQQQQ 2066_ QQQQQ 2071_ QQQQQ 2076_ QYHIR 2081_ QQQQQ 2086_ QILRQ 2091_ QQQQQ 2096_ QQQQQ 2101_ QQQQQ 2106_ QQQQQ 2111_ QQQQQ 2116_ HQQQQ 2121_ QQQAA 2126_ PPQPQ 2131_ PQSQP 2136_ QFQRQ 2141_ GLQQT 2146_ QQQQQ 2151_ TAALV 2156_ RQLQQ 2161_ QLSNT 2166_ QPQPS 2171_TNIFG
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway