Putative deoxyribonuclease TATDN2 (EC 3.1.21.-)
1_MASER 6_ GKVKH 11_ NWSST 16_ SEGCP 21_ RKRSC 26_ LREPC 31_ DVAPS 36_ SRPAQ 41_ RSASR 46_ SGGPS 51_ SPKRL 56_ KAQKE 61_ DDVAC 66_ SRRLS 71_ WGSSR 76_ RRNNS 81_ SSSFS 86_ PHFLG 91_ PGVGG 96_ AASKG 101_ CLIRN 106_ TRGFL 111_ SSGGS 116_ PLRPA 121_ NASLE 126_ EMASL 131_ EEEAC 136_ SLKVD 141_ SKDSS 146_ HNSTN 151_ SEFAA 156_ EAEGQ 161_ NDTIE 166_ EPNKV 171_ QKRKR 176_ DRLRD 181_ QGSTM 186_ IYLKA 191_ IQGIL 196_ GKSMP 201_ KRKGE 206_ AATRA 211_ KPSAA 216_ EHPSH 221_ GEGPA 226_ RSEGP 231_ AKTAE 236_ GAARS 241_ VTVTA 246_ AQKEK 251_ DATPE 256_ VSMEE 261_ DKTVP 266_ ERSSF 271_ YDRRV 276_ VIDPQ 281_ EKPSE 286_ EPLGD 291_ RRTVI 296_ DKCSP 301_ PLEFL 306_ DDSDS 311_ HLEIQ 316_ KHKDR 321_ EVVME 326_ HPSSG 331_ SDWSD 336_ VEEIS 341_ TVRFS 346_ QEEPV 351_ SLKPS 356_ AVPEP 361_ SSFTT 366_ DYVMY 371_ PPHLY 376_ SSPWC 381_ DYASY 386_ WTSSP 391_ KPSSY 396_ PSTGS 401_ SSNDA 406_ AQVGK 411_ SSRSR 416_ MSDYS 421_ PNSTG 426_ SVQNT 431_ SRDME 436_ ASEEG 441_ WSQNS 446_ RSFRF 451_ SRSSE 456_ EREVK 461_ EKRTF 466_ QEEMP 471_ PRPCG 476_ GHASS 481_ SLPKS 486_ HLEPS 491_ LEEGF 496_ IDTHC 501_ HLDML 506_ YSKLS 511_ FQGTF 516_ TKFRK 521_ IYSSS 526_ FPKEF 531_ QGCIS 536_ DFCDP 541_ RTLTD 546_ CLWEE 551_ LLKED 556_ LVWGA 561_ FGCHP 566_ HFARY 571_ YSESQ 576_ ERNLL 581_ QALRH 586_ PKAVA 591_ FGEMG 596_ LDYSY 601_ KCTTP 606_ VPEQH 611_ KVFER 616_ QLQLA 621_ VSLKK 626_ PLVIH 631_ CREAD 636_ EDLLE 641_ IMKKF 646_ VPPDY 651_ KIHRH 656_ CFTGS 661_ YPVIE 666_ PLLKY 671_ FPNMS 676_ VGFTA 681_ VLTYS 686_ SAWEA 691_ REALR 696_ QIPLE 701_ RIIVE 706_ TDAPY 711_ FLPRQ 716_ VPKSL 721_ CQYAH 726_ PGLAL 731_ HTVRE 736_ IARVK 741_ DQPLS 746_ LTLAA 751_ LRENT 756_SRLYS
1: Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292)