Ribonuclease K6 (RNase K6) (EC 3.1.27.-)
1_MVLCF 6_ PLLLL 11_ LLVLW 16_ GPVCP 21_ LHAWP 26_ KRLTK 31_ AHWFE 36_ IQHIQ 41_ PSPLQ 46_ CNRAM 51_ SGINN 56_ YTQHC 61_ KHQNT 66_ FLHDS 71_ FQNVA 76_ AVCDL 81_ LSIVC 86_ KNRRH 91_ NCHQS 96_ SKPVN 101_ MTDCR 106_ LTSGK 111_ YPQCR 116_ YSAAA 121_ QYKFF 126_ IVACD 131_ PPQKS 136_ DPPYK 141_LVPVH
1: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:27013146, PubMed:8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320)