KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)
1_MHTVA 6_ TSGPN 11_ ASWGA 16_ PANAS 21_ GCPGC 26_ GANAS 31_ DGPVP 36_ SPRAV 41_ DAWLV 46_ PLFFA 51_ ALMLL 56_ GLVGN 61_ SLVIY 66_ VICRH 71_ KPMRT 76_ VTNFY 81_ IANLA 86_ ATDVT 91_ FLLCC 96_ VPFTA 101_ LLYPL 106_ PGWVL 111_ GDFMC 116_ KFVNY 121_ IQQVS 126_ VQATC 131_ ATLTA 136_ MSVDR 141_ WYVTV 146_ FPLRA 151_ LHRRT 156_ PRLAL 161_ AVSLS 166_ IWVGS 171_ AAVSA 176_ PVLAL 181_ HRLSP 186_ GPRAY 191_ CSEAF 196_ PSRAL 201_ ERAFA 206_ LYNLL 211_ ALYLL 216_ PLLAT 221_ CACYA 226_ AMLRH 231_ LGRVA 236_ VRPAP 241_ ADSAL 246_ QGQVL 251_ AERAG 256_ AVRAK 261_ VSRLV 266_ AAVVL 271_ LFAAC 276_ WGPIQ 281_ LFLVL 286_ QALGP 291_ AGSWH 296_ PRSYA 301_ AYALK 306_ TWAHC 311_ MSYSN 316_ SALNP 321_ LLYAF 326_ LGSHF 331_ RQAFR 336_ RVCPC 341_ APRRP 346_ RRPRR 351_ PGPSD 356_ PAAPH 361_ AELLR 366_ LGSHP 371_ APARA 376_ QKPGS 381_ SGLAA 386_ RGLCV 391_LGEDN
1: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins