SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)
1_MSKRP 6_ SYAPP 11_ PTPAP 16_ ATQMP 21_ STPGF 26_ VGYNP 31_ YSHLA 36_ YNNYR 41_ LGGNP 46_ GTNSR 51_ VTASS 56_ GITIP 61_ KPPKP 66_ PDKPL 71_ MPYMR 76_ YSRKV 81_ WDQVK 86_ ASNPD 91_ LKLWE 96_ IGKII 101_ GGMWR 106_ DLTDE 111_ EKQEY 116_ LNEYE 121_ AEKIE 126_ YNESM 131_ KAYHN 136_ SPAYL 141_ AYINA 146_ KSRAE 151_ AALEE 156_ ESRQR 161_ QSRME 166_ KGEPY 171_ MSIQP 176_ AEDPD 181_ DYDDG 186_ FSMKH 191_ TATAR 196_ FQRNH 201_ RLISE 206_ ILSES 211_ VVPDV 216_ RSVVT 221_ TARMQ 226_ VLKRQ 231_ VQSLM 236_ VHQRK 241_ LEAEL 246_ LQIEE 251_ RHQEK 256_ KRKFL 261_ ESTDS 266_ FNNEL 271_ KRLCG 276_ LKVEV 281_ DMEKI 286_ AAEIA 291_ QAEEQ 296_ ARKRQ 301_ EEREK 306_ EAAEQ 311_ AERSQ 316_ SSIVP 321_ EEEQA 326_ ANKGE 331_ EKKDD 336_ ENIPM 341_ ETEET 346_ HLEET 351_ TESQQ 356_ NGEEG 361_ TSTPE 366_ DKESG 371_ QEGVD 376_ SMAEE 381_ GTSDS 386_ NTGSE 391_ SNSAT 396_ VEEPP 401_ TDPIP 406_EDEKK
1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells