Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)
1_MMPKH 6_ CFLGF 11_ LISFF 16_ LTGVA 21_ GTQST 26_ HESLK 31_ PQRVQ 36_ FQSRN 41_ FHNIL 46_ QWQPG 51_ RALTG 56_ NSSVY 61_ FVQYK 66_ IMFSC 71_ SMKSS 76_ HQKPS 81_ GCWQH 86_ ISCNF 91_ PGCRT 96_ LAKYG 101_ QRQWK 106_ NKEDC 111_ WGTQE 116_ LSCDL 121_ TSETS 126_ DIQEP 131_ YYGRV 136_ RAASA 141_ GSYSE 146_ WSMTP 151_ RFTPW 156_ WETKI 161_ DPPVM 166_ NITQV 171_ NGSLL 176_ VILHA 181_ PNLPY 186_ RYQKE 191_ KNVSI 196_ EDYYE 201_ LLYRV 206_ FIINN 211_ SLEKE 216_ QKVYE 221_ GAHRA 226_ VEIEA 231_ LTPHS 236_ SYCVV 241_ AEIYQ 246_ PMLDR 251_ RSQRS 256_EERCV
1: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses
2: Isoform 1 may play a role in establishing and maintaining successful pregnancy