E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
1_MKAGA 6_ TSMWA 11_ SCCGL 16_ LNEVM 21_ GTGAV 26_ RGQQS 31_ AFAGA 36_ TGPFR 41_ FTPNP 46_ EFSTY 51_ PPAAT 56_ EGPNI 61_ VCKAC 66_ GLSFS 71_ VFRKK 76_ HVCCD 81_ CKKDF 86_ CSVCS 91_ VLQEN 96_ LRRCS 101_ TCHLL 106_ QETAF 111_ QRPQL 116_ MRLKV 121_ KDLRQ 126_ YLILR 131_ NIPID 136_ TCREK 141_ EDLVD 146_ LVLCH 151_ HGLGS 156_ EDDMD 161_ TSSLN 166_ SSRSQ 171_ TSSFF 176_ TRSFF 181_ SNYTA 186_ PSATM 191_ SSFQG 196_ ELMDG 201_ DQTSR 206_ SGVPA 211_ QVQSE 216_ ITSAN 221_ TEDDD 226_ DDDDE 231_ DDDDE 236_ EENAE 241_ DRNPG 246_ LSKER 251_ VRASL 256_ SDLSS 261_ LDDVE 266_ GMSVR 271_ QLKEI 276_ LARNF 281_ VNYSG 286_ CCEKW 291_ ELVEK 296_ VNRLY 301_ KENEE 306_ NQKSY 311_ GERLQ 316_ LQDEE 321_ DDSLC 326_ RICMD 331_ AVIDC 336_ VLLEC 341_ GHMVT 346_ CTKCG 351_ KRMSE 356_ CPICR 361_ QYVVR 366_AVHVF
1: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219)