Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
1_MGALR 6_ PTLLP 11_ PSLPL 16_ LLLLM 21_ LGMGC 26_ WAREV 31_ LVPEG 36_ PLYRV 41_ AGTAV 46_ SISCN 51_ VTGYE 56_ GPAQQ 61_ NFEWF 66_ LYRPE 71_ APDTA 76_ LGIVS 81_ TKDTQ 86_ FSYAV 91_ FKSRV 96_ VAGEV 101_ QVQRL 106_ QGDAV 111_ VLKIA 116_ RLQAQ 121_ DAGIY 126_ ECHTP 131_ STDTR 136_ YLGSY 141_ SGKVE 146_ LRVLP 151_ DVLQV 156_ SAAPP 161_ GPRGR 166_ QAPTS 171_ PPRMT 176_ VHEGQ 181_ ELALG 186_ CLART 191_ STQKH 196_ THLAV 201_ SFGRS 206_ VPEAP 211_ VGRST 216_ LQEVV 221_ GIRSD 226_ LAVEA 231_ GAPYA 236_ ERLAA 241_ GELRL 246_ GKEGT 251_ DRYRM 256_ VVGGA 261_ QAGDA 266_ GTYHC 271_ TAAEW 276_ IQDPD 281_ GSWAQ 286_ IAEKR 291_ AVLAH 296_ VDVQT 301_ LSSQL 306_ AVTVG 311_ PGERR 316_ IGPGE 321_ PLELL 326_ CNVSG 331_ ALPPA 336_ GRHAA 341_ YSVGW 346_ EMAPA 351_ GAPGP 356_ GRLVA 361_ QLDTE 366_ GVGSL 371_ GPGYE 376_ GRHIA 381_ MEKVA 386_ SRTYR 391_ LRLEA 396_ ARPGD 401_ AGTYR 406_ CLAKA 411_ YVRGS 416_ GTRLR 421_ EAASA 426_ RSRPL 431_ PVHVR 436_ EEGVV 441_ LEAVA 446_ WLAGG 451_ TVYRG 456_ ETASL 461_ LCNIS 466_ VRGGP 471_ PGLRL 476_ AASWW 481_ VERPE 486_ DGELS 491_ SVPAQ 496_ LVGGV 501_ GQDGV 506_ AELGV 511_ RPGGG 516_ PVSVE 521_ LVGPR 526_ SHRLR 531_ LHSLG 536_ PEDEG 541_ VYHCA 546_ PSAWV 551_ QHADY 556_ SWYQA 561_ GSARS 566_ GPVTV 571_ YPYMH 576_ ALDTL 581_ FVPLL 586_ VGTGV 591_ ALVTG 596_ ATVLG 601_ TITCC 606_FMKRL
1: Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, PubMed:14662754). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities (PubMed:17785435). In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation (PubMed:22689882). Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry (PubMed:23351194). Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion (PubMed:31757023). Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain